Trauma Research Center, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Adv Exp Med Biol. 2021;1321:261-264. doi: 10.1007/978-3-030-59261-5_23.
Identification of the causal risk factors of COVID-19 would allow better risk stratification and designing effective therapies. Epidemiological data have shown a higher incidence and mortality of COVID-19 in males compared to females. Here, we have used logistic regression analysis modeling to determine the association between gender and COVID-19 mortality in the Iranian population. The records of 2293 patients with COVID-19 infection were analyzed. The odds of death due to COVID-19 were 1.7 times higher in males compared to females after adjustment for age and background diseases. The gender difference was mainly observed at higher ages, suggesting an adjusted 2.32-fold higher risk of mortality in males aged >59.5 years old compared to females within the same age group. This finding suggests the male gender is a potential predisposing factor for mortality due to COVID-19 infection. The potential role of male hormones, particularly testosterone, as therapeutic targets deserves further investigation.
确定 COVID-19 的因果风险因素将有助于更好地进行风险分层和制定有效的治疗方法。流行病学数据显示，男性 COVID-19 的发病率和死亡率高于女性。在这里，我们使用逻辑回归分析模型来确定性别与伊朗人群 COVID-19 死亡率之间的关联。分析了 2293 例 COVID-19 感染患者的记录。在调整年龄和基础疾病后，男性 COVID-19 死亡率是女性的 1.7 倍。这种性别差异主要出现在较高的年龄组，这表明在相同年龄组中，年龄>59.5 岁的男性 COVID-19 死亡率的调整风险比女性高 2.32 倍。这一发现表明男性性别是 COVID-19 感染导致死亡的潜在易感因素。男性激素，特别是睾酮，作为治疗靶点的潜在作用值得进一步研究。
