Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
J Sex Med. 2021 May;18(5):843-848. doi: 10.1016/j.jsxm.2021.03.004. Epub 2021 Mar 19.
COVID-19 consistently displays a higher mortality in males. This sex-specific difference in outcomes is seen not only in the current COVID-19 pandemic, but also in prior viral epidemics and pandemics. Sex hormones, such as testosterone, play a clear role in modulating the immune response, providing a clue that may illuminate the underpinnings of these outcomes. Developing a deeper understanding of these epidemiological findings permits a more effective response to the disease. This article summarizes the sex-specific COVID-19 outcomes, the role of androgens in generating these outcomes, and the potential role of modifying testosterone levels as a form of treatment of COVID-19. Auerbach JM, Khera M. Testosterone's Role in COVID-19. J Sex Med 2021;18:843-848.
新冠病毒（COVID-19）始终在男性中显示出更高的死亡率。这种在结果上的性别特异性差异不仅在当前的 COVID-19 大流行中，而且在之前的病毒流行和大流行中都有体现。睾丸激素等性激素在调节免疫反应方面发挥着明显的作用，这为阐明这些结果的基础提供了线索。深入了解这些流行病学发现可以使我们更有效地应对这种疾病。本文总结了 COVID-19 结果的性别特异性，雄激素在产生这些结果中的作用，以及改变睾丸激素水平作为 COVID-19 治疗形式的潜在作用。Auerbach JM, Khera M. Testosterone's Role in COVID-19. J Sex Med 2021;18:843-848.
