从苦参中分离得到的 5 种苦参碱型生物碱。
Five matrine-type alkaloids from Sophora tonkinensis.
机构信息
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, People's Republic of China.
Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, 510632, People's Republic of China.
出版信息
J Nat Med. 2021 Jun;75(3):682-687. doi: 10.1007/s11418-021-01498-x. Epub 2021 Mar 3.
Five matrine-type alkaloids (1‒5) including two new compounds (1 and 3) and a new natural product (2) were isolated from the roots of Sophora tonkinesis. Their structures were identified by extensive spectroscopic analysis (UV, IR, HRESIMS and NMR). The absolute configurations of 2 and 3 were determined by X-ray diffraction. Compounds 1‒5 were evaluated their activity against inflammatory cytokines TNF-α and IL-6 levels on LPS-induced RAW 264.7 macrophages, and compound 1 showed the most significant activity, potent than that of matrine, the representative ingredient from Sophora plants.
从苦参根部分离得到了五个苦参碱型生物碱（1-5），包括两个新化合物（1 和 3）和一个新天然产物（2）。通过广泛的光谱分析（UV、IR、HRESIMS 和 NMR）确定了它们的结构。通过 X 射线衍射确定了 2 和 3 的绝对构型。对化合物 1-5 进行了活性评价，它们对 LPS 诱导的 RAW 264.7 巨噬细胞中炎症细胞因子 TNF-α 和 IL-6 水平的抑制活性，化合物 1 表现出最显著的活性，比苦参的代表性成分苦参碱更强。
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