Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
JBJS Case Connect. 2021 Mar 3;11(1):01709767-202103000-00038. doi: e20.00296.
Gorham-Stout disease (GSD) is a rare disorder characterized by progressive localized osteolysis and lymphatic malformation. A 26-year-old woman with GSD presented to our hospital with a Cobb angle of 100° and a kyphosis angle of 88°. Everolimus therapy was initiated to control the disease prior to surgery. After halo-gravity traction for 4 weeks, we performed anterior and posterior spinal fusion. Postoperative computed tomography revealed satisfactory bone union and no significant loss of correction 1 year post-surgery.
This case suggests that anterior and posterior spinal fusion combined with everolimus therapy can be a therapeutic option for GSD.
Gorham-Stout 病（GSD）是一种罕见疾病，其特征为进行性局部骨质溶解和淋巴管畸形。一名 26 岁女性患有 GSD，就诊时 Cobb 角为 100°，后凸角为 88°。在手术前，采用依维莫司治疗来控制疾病。 halo-gravity 牵引 4 周后，我们进行了前后路脊柱融合术。术后 CT 显示术后 1 年骨愈合满意，矫正无明显丢失。
本病例提示前后路脊柱融合术联合依维莫司治疗可能是 GSD 的一种治疗选择。
