Department of Ultrasound，The First Affiliated Hospital of Chongqing Medical University，Chongqing，China.
Med Ultrason. 2021 Aug 11;23(3):305-310. doi: 10.11152/mu-2940. Epub 2021 Mar 1.
This study aims to investigate the biomechanical properties of the posterior eye using the shear wave elastography (SWE) in increased intracranial pressure (ICP) patients and healthy subjects.
This study enrolled 54 healthy subjects and 54 patients with increased ICP, including 29 patients with space-occupying lesions (SOLs) and 25 patients with intracranial haemorrhage (ICH). Optic nerve sheath diameter and the stiffness of the optic nerve head, peripapil-lary sclera and optic nerve were evaluated.
Patients with increased ICP had a significantly higher optic nerve sheath diameter, Young's modulus of optic nerve head, and Young's modulus of peripapillary sclera than healthy subjects (p<0.01 for all). The optic nerve sheath diameter, Young's modulus of optic nerve head and Young's modulus of the peripapillary sclera were similar between the SOLs group and ICH group (p>0.05 for all). Young's modulus of the optic nerve in the ICH group was similar to the control group (p>0.05), whereas the SOLs group had higher Young's modulus of optic nerve comparing the control group (p<0.05).
The stiffness of the optic nerve head and peripapillary sclera were higher in patients with increased ICP than healthy subjects, and the optic nerve stiffness of SOLs patients was the highest in all subjects. The SWE could provide a quantitative analysis of the posterior eye's biomechanical properties and help the clinic diagnose the degree of visual impairments.
本研究旨在使用剪切波弹性成像（SWE）研究颅内压升高（ICP）患者的后眼部的生物力学特性。
本研究纳入了 54 名健康受试者和 54 名 ICP 升高患者，包括 29 名占位性病变（SOL）患者和 25 名颅内出血（ICH）患者。评估视神经鞘直径以及视盘周围巩膜和视神经的硬度。
ICP 升高的患者的视神经鞘直径、视盘硬度、视盘周围巩膜硬度均显著高于健康受试者（p<0.01）。SOL 组和 ICH 组之间的视神经鞘直径、视盘硬度和视盘周围巩膜硬度无显著差异（p>0.05）。ICH 组的视神经硬度与对照组相似（p>0.05），而 SOL 组的视神经硬度高于对照组（p<0.05）。
ICP 升高患者的视盘硬度和视盘周围巩膜硬度高于健康受试者，而 SOL 患者的视神经硬度在所有受试者中最高。SWE 可以提供后眼部生物力学特性的定量分析，并有助于临床诊断视力损害程度。
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