Center of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, 58 2nd Zhongshan Road, Guangzhou, 510080, Guangdong, People's Republic of China.
Department of Pathology, The First Affiliated Hospital of Sun Yat-Sen University, 58 2nd Zhongshan Road, Guangzhou, 510080, Guangdong, People's Republic of China.
BMC Surg. 2021 Mar 3;21(1):111. doi: 10.1186/s12893-021-01088-4.
Gastrointestinal stromal tumor (GIST) can arise anyplace along the gastrointestinal (GI) tract. The uncommon tumor location in groin area is rarely reported.
We herein reported a metastasized case presented as GI hemorrhage complicated with indirect hernia, and underwent tumor cytoreduction, herniorrhaphy and chemotherapy for jejunal GIST. The case was described consecutively based on the process of surgical management, with a good follow-up result. A literature review by searching similar case reports from two national medical databases was performed to summarize clinical features of such unusual presentation of GIST, which included hernia characteristics, short- and long-term outcomes of this disease. It showed GIST presenting as groin hernia was rarely reported and all available 11 cases suggested a primary tumor and required both tumor resection and hernia repair. The long-term results indicated 64.3% overall survival at 5 years after the incidental diagnosis.
Inguinal hernia is an extremely rare presentation of GIST, with limited case reports available in the literature. A radical involving tumor resection plus hernia repair is an optimal surgical approach for such uncommon condition. An adjuvant medication mounting on mutated KIT gene should be strictly followed for high risk cases.
胃肠道间质瘤（GIST）可发生于胃肠道（GI）的任何部位。发生于腹股沟区的罕见肿瘤位置很少有报道。
我们在此报告了一例转移性病例，表现为胃肠道出血合并腹股沟间接疝，并接受了空肠 GIST 的肿瘤细胞减灭术、疝修补术和化疗。该病例根据手术管理过程进行了连续描述，具有良好的随访结果。通过在两个国家医学数据库中搜索类似的病例报告进行文献回顾，总结了 GIST 这种不常见表现的临床特征，包括疝的特征、该疾病的短期和长期结局。结果表明，表现为腹股沟疝的 GIST 很少有报道，所有可获得的 11 例均提示存在原发性肿瘤，需要进行肿瘤切除和疝修补。长期结果表明，在偶然诊断后 5 年的总生存率为 64.3%。
腹股沟疝是 GIST 极为罕见的表现，文献中仅有有限的病例报告。对于这种罕见情况，涉及肿瘤切除加疝修补的根治性手术是最佳的手术方法。对于高危病例，应严格遵循基于突变 KIT 基因的辅助药物治疗。
