Department of Gastroenterology, The Second Hospital of Jilin University, No. 218, Ziqiang Street, Changchun, 130042, China.
Department of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital of Jilin University, Changchun, China.
World J Surg Oncol. 2017 Dec 13;15(1):220. doi: 10.1186/s12957-017-1285-2.
Gastrointestinal stromal tumors (GISTs) rarely present with predominantly cystic changes. Here, we report a case of giant GIST of the stomach with predominantly cystic changes in a 74-year-old female patient.
The tumor was 10 cm × 15 cm in size and positive for CD117, H-caldesmon, and DOG-1. Complete surgical resection was performed without regional lymphadenectomy. The patient recovered uneventfully and no recurrence occurred.
The case illustrates that GIST with cystic changes should be considered in the diagnoses of hepatic and pancreatic lesions. Furthermore, immunohistochemistry with CD117, DOG1, and other molecular markers is critical for diagnosis of GIST of the stomach and facilitates optimization of treatments for GIST.
胃肠道间质瘤（GIST）很少表现为主要囊性改变。在此，我们报告一例 74 岁女性患者胃内巨大 GIST，主要为囊性改变。
肿瘤大小为 10cm×15cm，CD117、H-钙调蛋白和 DOG-1 阳性。行完全手术切除，无区域淋巴结清扫。患者恢复顺利，无复发。
该病例表明，对于肝、胰病变，应考虑囊性改变的 GIST。此外，CD117、DOG1 及其他分子标志物的免疫组织化学检测对胃 GIST 的诊断至关重要，并有助于优化 GIST 的治疗。
