Ningxia Medical University, General Hospital of Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
Reproductive Medicine Center, General Hospital of Ningxia Medical University, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
Stem Cell Res Ther. 2021 Mar 3;12(1):161. doi: 10.1186/s13287-021-02212-0.
Premature ovarian failure (POF) is one of the common disorders found in women leading to 1% female infertility. Clinical features of POF are hypoestrogenism or estrogen deficiency, increased gonadotropin level, and, most importantly, amenorrhea. With the development of regenerative medicine, human mesenchymal stem cell (hMSC) therapy brings new prospects for POF. This study aimed to describe the types of MSCs currently available for POF therapy, their biological characteristics, and their mechanism of action. It reviewed the latest findings on POF to provide the theoretical basis for further investigation and clinical therapy.
卵巢早衰（POF）是导致 1%女性不孕的常见疾病之一。POF 的临床特征是雌激素缺乏或低下、促性腺激素水平升高，最重要的是闭经。随着再生医学的发展，人类间充质干细胞（hMSC）治疗为 POF 带来了新的前景。本研究旨在描述目前用于 POF 治疗的 MSC 类型、它们的生物学特性及其作用机制。它综述了 POF 的最新发现，为进一步的研究和临床治疗提供了理论基础。
