Pirovano Ileana, Porcelli Simone, Re Rebecca, Spinelli Lorenzo, Contini Davide, Marzorati Mauro, Torricelli Alessandro
Dipartimento di Fisica, Politecnico di Milano, Milan, Italy.
Istituto di Tecnologie Biomediche, Consiglio Nazionale delle Ricerche, Segrate, Milan, Italy.
Biomed Opt Express. 2020 Dec 22;12(1):571-587. doi: 10.1364/BOE.412447. eCollection 2021 Jan 1.
We propose a quantitative and systematic investigation of the differential pathlength factor (DPF) behavior for skeletal muscles and its dependence on different factors, such as the subcutaneous adipose tissue thickness (ATT), the variations of the tissue absorption ( ) and reduced scattering ( ) coefficients, and the source-detector distance. A time domain (TD) NIRS simulation study is performed in a two-layer geometry mimicking a human skeletal muscle with an overlying adipose tissue layer. The DPF decreases when increases, while it increases when increases. Moreover, a positive correlation between DPF and ATT is found. These results are supported by an TD NIRS study on and muscles of eleven subjects at rest, showing a high inter-subject and inter-muscle variability.
我们提议对骨骼肌的微分程长因子（DPF）行为及其对不同因素的依赖性进行定量和系统的研究，这些因素包括皮下脂肪组织厚度（ATT）、组织吸收（ ）和约化散射（ ）系数的变化以及源探测器距离。在模拟具有上层脂肪组织层的人体骨骼肌的双层几何结构中进行了时域（TD）近红外光谱模拟研究。当 增加时，DPF降低，而当 增加时，DPF增加。此外，发现DPF与ATT之间存在正相关。这些结果得到了一项针对11名受试者休息时的 和 肌肉的时域近红外光谱研究的支持，该研究显示出较高的个体间和肌肉间变异性。
