用于探索细菌细胞壁结构与动态变化的更新工具包。
An updated toolkit for exploring bacterial cell wall structure and dynamics.
作者信息
Gilmore Michael C, Ritzl-Rinkenberger Barbara, Cava Felipe
机构信息
Laboratory for Molecular Infection Medicine Sweden (MIMS), Department of Molecular Biology, Umeå University, Umeå, Sweden.
出版信息
Fac Rev. 2021 Feb 10;10:14. doi: 10.12703/r/10-14. eCollection 2021.
The bacterial cell wall is made primarily from peptidoglycan, a complex biomolecule which forms a bag-like exoskeleton that envelops the cell. As it is unique to bacteria and typically essential for their growth and survival, it represents one of the most successful targets for antibiotics. Although peptidoglycan has been studied intensively for over 50 years, the past decade has seen major steps in our understanding of this molecule because of the advent of new analytical and imaging methods. Here, we outline the most recent developments in tools that have helped to elucidate peptidoglycan structure and dynamics.
细菌细胞壁主要由肽聚糖构成，肽聚糖是一种复杂的生物分子，形成一个包裹细胞的袋状外骨骼。由于它是细菌所特有的，并且通常对其生长和存活至关重要，因此它是抗生素最成功的靶点之一。尽管肽聚糖已经被深入研究了50多年，但由于新的分析和成像方法的出现，在过去十年里，我们对这种分子的理解取得了重大进展。在这里，我们概述了有助于阐明肽聚糖结构和动力学的工具的最新进展。
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