男性不育诊断与治疗的最新进展及争议

Ambar Rafael F, Parekh Neel, Agarwal Ashok

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

Urology Department of Faculdade de Medicina do ABC - FMABC/Andrology Group at Ideia Fertil Institute of Human Reproduction, Santo André, SP, Brazil.

Fac Rev. 2020 Dec 10;9:22. doi: 10.12703/r/22. eCollection 2020.

Interest in male infertility has increased, as it plays an important role in up to 50% of couples struggling with infertility, which is an estimated 48.5 million couples globally. Despite recent advances, diagnosing and treating male infertility remain a significant clinical challenge owing to complex multifactorial pathways and the diversity of treatment options. This review will assess current controversial topics on male infertility such as the use of home-based semen testing, management of subclinical varicocele, and recent advances in the field of sperm proteomics.

对男性不育症的关注有所增加，因为在全球约4850万受不孕症困扰的夫妇中，高达50%的夫妇中男性不育症起着重要作用。尽管最近取得了进展，但由于复杂的多因素途径和治疗选择的多样性，男性不育症的诊断和治疗仍然是一项重大的临床挑战。本综述将评估男性不育症当前存在争议的话题，如家庭精液检测的使用、亚临床精索静脉曲张的管理以及精子蛋白质组学领域的最新进展。