Feng X, Zhang F Q, Xu F Y, Mei X F, Zhang Z C, Li X R, Wang S
School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.
Xinxiang Key Laboratory of Pathogenic Biology, Xinxiang Medical University, China.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2020 Oct 28;33(1):102-106. doi: 10.16250/j.32.1374.2020162.
is a common parasitic protozoa in human and animal intestines; however, its pathogenicity remains controversial. Construction of animal models is of great significance to investigate the pathogenicity, pathogenic mechanisms and drug screening of . Experimental animals, mode of infections, parasite strains and host immune status are important factors affecting the successful modeling of infections in animals. Hereby, we review the progress of researches on animal models of infections, and summarize the influencing factors and application of animal models of infections, in order to provides insights into the selection of animals models of infections.
是人和动物肠道中常见的寄生原生动物；然而，其致病性仍存在争议。构建动物模型对于研究其致病性、致病机制和药物筛选具有重要意义。实验动物、感染方式、寄生虫菌株和宿主免疫状态是影响动物感染成功建模的重要因素。在此，我们综述了感染动物模型的研究进展，总结了感染动物模型的影响因素及应用，以期为感染动物模型的选择提供参考。
