Ersahin S S, Yurci A
Department of Obstetrics and Gynecology, Altınbas University, Istanbul, Turkey.
Eur Rev Med Pharmacol Sci. 2021 Feb;25(4):1954-1958. doi: 10.26355/eurrev_202102_25095.
The aim of this study is to examine the maternal serum and cord blood irisin and preptin levels in gestational diabetes mellitus (GDM) and correlate their levels with demographic and biochemical parameters.
A total of 21 pregnant women with GDM and 21 BMI and age-matched pregnant women without GDM were included in the study. They underwent 50 g glucose challenge test (GCT) between 24-28th gestational weeks. Women with a GCT result higher than 140 mg/dl received 100 g oral glucose tolerance test (OGTT). Detection of one of the following criteria after OGTT was accepted as GDM: fasting plasma glucose level 92 mg/dL; 1-h plasma glucose level 180 mg/dL; and 2-h plasma glucose 153 mg/dL. Correlation between metabolic parameters and cord blood and maternal serum preptin and irisin levels in GDM and non-GDM subjects were analyzed.
Maternal serum preptin values of GDM subjects were similar to the serum preptin values of non-GDM control subjects (123.12±34.3 pg/mL vs. 112.02±12.0 pg/mL, p<0.23). Cord blood preptin levels of GDM (64.3±1.09 pg/mL vs. 123.12±34.3 pg/mL, p<0.03) and non-GDM subjects (59.2±021 pg/mL vs. 112.02±12.0 pg/mL, p<0.02) were significantly lower than the maternal serum preptin values. Serum preptin levels of GDM group were positively correlated with HOMA-IR (r=0.33, p<0.04), but not with other parameters. Maternal serum irisin levels in the GDM group were lower than the non-GDM control group (5.32±0.44 µg/mL vs. 7.74±4.52 µg/mL, p<0.01). Cord blood irisin concentrations were found similar in women with GDM and non-GDM subjects (4.91±3.12 µg/mL vs. 5.01±2.14 µg/mL, p<0.14). Cord blood irisin levels of GDM subjects were similar to maternal serum irisin levels (4.91±3.12 µg/mL vs. 5.32±0.44 µg/mL, p<0.57). We found positive correlation between irisin concentration and fasting insulin, HOMA-IR, and BMI in women with GDM. In subgroup analysis of 6 patients using insulin treatment, serum and cord blood irisin and preptin levels were similar to those that did not use insulin.
Maternal serum and cord blood preptin and irisin concentrations are regulated independently in women with GDM.
本研究旨在检测妊娠期糖尿病（GDM）患者母血及脐血中鸢尾素和前ptin水平，并将其水平与人口统计学和生化参数进行关联分析。
本研究共纳入21例GDM孕妇和21例体重指数（BMI）及年龄匹配的非GDM孕妇。她们在孕24 - 28周期间接受了50克葡萄糖耐量试验（GCT）。GCT结果高于140毫克/分升的女性接受100克口服葡萄糖耐量试验（OGTT）。OGTT后符合以下任一标准者被诊断为GDM：空腹血糖水平92毫克/分升；1小时血糖水平180毫克/分升；2小时血糖水平153毫克/分升。分析了GDM和非GDM受试者代谢参数与脐血及母血前ptin和鸢尾素水平之间的相关性。
GDM受试者母血前ptin值与非GDM对照组血清前ptin值相似（123.12±34.3皮克/毫升对112.02±12.0皮克/毫升，p<0.23）。GDM组（64.3±1.09皮克/毫升对123.12±34.3皮克/毫升，p<0.03）和非GDM组（59.2±0.21皮克/毫升对112.02±12.0皮克/毫升，p<0.02）的脐血前ptin水平均显著低于母血前ptin值。GDM组血清前ptin水平与胰岛素抵抗指数（HOMA-IR）呈正相关（r = 0.33，p<0.04），但与其他参数无相关性。GDM组母血鸢尾素水平低于非GDM对照组（5.32±0.44微克/毫升对7.74±4.52微克/毫升，p<0.01）。GDM组和非GDM组的脐血鸢尾素浓度相似（4.91±3.12微克/毫升对5.01±2.14微克/毫升，p<0.14）。GDM受试者的脐血鸢尾素水平与母血鸢尾素水平相似（4.91±3.12微克/毫升对5.32±0.44微克/毫升，p<0.57）。我们发现GDM女性中鸢尾素浓度与空腹胰岛素、HOMA-IR和BMI呈正相关。在6例使用胰岛素治疗患者的亚组分析中，血清和脐血鸢尾素及前ptin水平与未使用胰岛素者相似。
GDM女性母血及脐血前ptin和鸢尾素浓度受到独立调节。
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