Rossini Gajšak Linda, Vogrinc Željka, Čelić Ružić Mirela, Bošnjak Kuharić Dina, Bošković Marija, Koričančić Makar Ana, Makarić Porin, Ermakora Vesna, Kekin Ivana, Bajić Žarko, Rojnić Kuzman Martina
Martina Rojnić Kuzman, Department of Psychiatry, University Hospital Center Zagreb, Kišpatićeva 12, HR-10000 Zagreb, Croatia,
Croat Med J. 2021 Feb 28;62(1):80-89. doi: 10.3325/cmj.2021.62.80.
To analyze the difference in the salivary cortisol response to psychosocial stress between the patients with the first episode of psychosis (FEP) and the control group.
We performed a cross-sectional analysis of the baseline measurements of a prospective cohort study conducted from 2015 to 2018 at two Croatian psychiatric hospitals. The study consecutively enrolled 53 patients diagnosed with FEP and 63 healthy controls. The primary outcome was the difference in the changes of salivary cortisol concentration during the stress test. The secondary outcome was the difference in the baseline levels of salivary cortisol between patients with FEP and controls. The tertiary outcome were the correlations of salivary cortisol levels with the results of the Positive and Negative Syndrome Scale for Schizophrenia, Rosenberg Self-Esteem Scale, and the International Personality Item Pool.
Patients with FEP had significantly higher baseline salivary cortisol than controls, but their salivary cortisol increased significantly less during the stress test.
Patients with FEP respond differently to stressful stimuli than controls, as shown by the increased baseline salivary cortisol and blunted cortisol response, possibly indicating a greater vulnerability to psychosocial stress.
分析首发精神病（FEP）患者与对照组在心理社会应激下唾液皮质醇反应的差异。
我们对2015年至2018年在两家克罗地亚精神病医院进行的一项前瞻性队列研究的基线测量进行了横断面分析。该研究连续纳入了53例被诊断为FEP的患者和63名健康对照者。主要结局是应激测试期间唾液皮质醇浓度变化的差异。次要结局是FEP患者与对照者唾液皮质醇基线水平的差异。三级结局是唾液皮质醇水平与精神分裂症阳性和阴性症状量表、罗森伯格自尊量表以及国际个性项目池结果的相关性。
FEP患者的唾液皮质醇基线水平显著高于对照组，但在应激测试期间其唾液皮质醇的增加显著较少。
FEP患者与对照组对压力刺激的反应不同，表现为唾液皮质醇基线水平升高和皮质醇反应减弱，这可能表明其对心理社会应激的易感性更高。
