Mancardi G L, Romagnoli P, Tassinari T, Gandolfo C, Primavera A, Loeb C
Istituto di Clinica Neurologica, Università di Genova, Italia.
Eur Neurol. 1988;28(1):11-7. doi: 10.1159/000116220.
Fifty-one brains showing lacunae and 30 with cribriform cavities have been identified out of 191 examined brains. A histologic and immunohistochemical study with the peroxidase-antiperoxidase method for glial fibrillary acidic protein has been carried out in selected cases. The number, site, associated arterial lesions and the microscopic appearance of lacunae and cribriform cavities are reported. Lacunae are small cavities usually, but not always due to softenings; cribriform cavities are dilatations of the perivascular space. Two types of cribriform cavities have been identified, according to the histological appearance of the surrounding tissue: type 1 with normal and type 2 with rarefied and abnormally gliotic surrounding nervous tissue. Sixteen cases showing a cribriform state in the basal ganglia exhibited a pseudobulbar palsy or extrapyramidal rigidity. Pseudobulbar palsy of striate form or parkinsonism may be ascertained in some cases only by histological and immunohistochemical examination.
在191例被检查的大脑中，发现51例有腔隙，30例有筛状腔。对部分病例采用过氧化物酶-抗过氧化物酶法进行了胶质纤维酸性蛋白的组织学和免疫组织化学研究。报告了腔隙和筛状腔的数量、位置、相关动脉病变以及微观表现。腔隙通常是小腔，但并非总是由软化引起；筛状腔是血管周围间隙的扩张。根据周围组织的组织学表现，确定了两种类型的筛状腔：1型周围神经组织正常，2型周围神经组织稀疏且有异常胶质增生。16例基底节出现筛状状态的病例表现为假性延髓麻痹或锥体外系强直。某些情况下，仅通过组织学和免疫组织化学检查才能确定条纹状假性延髓麻痹或帕金森病。
