解析恐惧引起的食欲抑制的神经回路。
Dissecting the neural circuitry of fear-induced appetite suppression.
机构信息
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Neuron. 2021 Mar 3;109(5):746-747. doi: 10.1016/j.neuron.2021.02.008.
Abstract
The circuit that links stress and fear to feeding behavior is poorly understood. In this issue of Neuron, Yang et al. detail a trisynaptic, cannabinoid-dependent circuit that underlies appetite suppression in response to a fearful stimulus and provide evidence of noradrenaline and glutamate co-transmission in locus coeruleus.
摘要
链接压力和恐惧与进食行为的回路知之甚少。在本期《神经元》中，Yang 等人详细描述了一个三突触、依赖大麻素的回路，该回路是对恐惧刺激产生的食欲抑制的基础，并提供了蓝斑核中去甲肾上腺素和谷氨酸共传递的证据。
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本文引用的文献
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Neuron. 2021 Mar 3;109(5):823-838.e6. doi: 10.1016/j.neuron.2020.12.023. Epub 2021 Jan 20.
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Deciphering a neuronal circuit that mediates appetite.解析介导食欲的神经元回路。
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Existence of glutamate in noradrenergic locus coeruleus neurons of rodents.啮齿动物去甲肾上腺素能蓝斑核神经元中谷氨酸的存在。
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