Hendriks L, De Baere R, Van Broeckhoven C, De Wachter R
Departement Biochemie, Universiteit Antwerpen (UIA), Belgium.
FEBS Lett. 1988 May 9;232(1):115-20. doi: 10.1016/0014-5793(88)80398-3.
The sequence of the 18 S rRNA of Tenebrio molitor is reported. A detailed secondary structure model for eukaryotic small subunit rRNAs is proposed. The model comprises 48 universal helices that eukaryotic and prokaryotic small subunit rRNAs have in common, plus a number of helices in areas of variable secondary structure. For the central area of the model, an alternative structure is possible, applicable only to eukaryotic small subunit rRNAs. Possibly, small subunit rRNA switched to this alternative conformation after the eukaryotic branch had been established in evolution. Another possibility is that the two conformers represent a dynamic structural switch functioning during the translational activity of the eukaryotic ribosome.
报道了黄粉虫18 S rRNA的序列。提出了真核小亚基rRNA的详细二级结构模型。该模型包括真核和原核小亚基rRNA共有的48个通用螺旋，以及可变二级结构区域中的一些螺旋。对于模型的中心区域，存在一种仅适用于真核小亚基rRNA的替代结构。在进化过程中，真核分支建立后，小亚基rRNA可能切换到这种替代构象。另一种可能性是，这两种构象代表了真核核糖体翻译活性期间起作用的动态结构转换。
