The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei.
Shanxi Province Hospital of Traditional Chinese Medical, Taiyuan.
Medicine (Baltimore). 2021 Feb 26;100(8):e24879. doi: 10.1097/MD.0000000000024879.
Persistent and intractable hiccups are a common clinical symptom that cause considerable physical pain to patients and severely damage their quality of lives. An increasing number of studies have demonstrated that acupuncture applied at acupoints dominated by Cuanzhu (BL2) can be used as one of the nonpharmacological therapies for controlling intractable hiccups. However, there is insufficient evidence evaluating the safety and effectiveness of those interventions. Therefore, this study is intended to conduct a systematic review and meta-analysis to provide evidence for a further study investigating alternative treatment options for persistent and intractable hiccups.
Randomized controlled trials (RCTs) of adult patients aged >18 years who meet the criteria for intractable hiccup diagnosis will be included, regardless of gender, nationality, and education level. Eight electronic databases will be searched, including 4 Chinese databases (CNKI, SinoMed, Wanfang Database, and Chinese Scientific Journal Database), 4 English databases (Web of Science, Medline, Embase, and Cochrane Library), from their date of establishment to September 2020. Two independent reviewers will evaluate the title summary for each RCT. Disagreements will be discussed with a third commentator. Data integration, heterogeneity analysis, subgroup analysis, and sensitivity analysis, will be performed using R-3.3.2 software. The RevMan 5.3 software will be used for the meta-analysis, and the "risk of bias" assessment will be conducted based on the methodological quality of the included trials recommended by the Cochrane Handbook 5.1. The quality evaluation of this study will be completed by the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE).
This study will summarize all the selected trials aimed at estimating the effectiveness, as well as safety, of applying acupuncture at acupoints dominated by Cuanzhu (BL2) to persistent and intractable hiccups.
This systematic review will provide evidence to assess the validity and safety of applying acupuncture at acupoints dominated by Cuanzhu (BL2) for persistent and intractable hiccups, which may provide clinicians with more choices in the treatment of this disease.
CRD42020114900.
持续性和顽固性呃逆是一种常见的临床症状，会给患者带来极大的身体疼痛，并严重影响其生活质量。越来越多的研究表明，针刺以攒竹穴（BL2）为主的穴位可以作为控制顽固性呃逆的非药物治疗方法之一。然而，目前评估这些干预措施的安全性和有效性的证据还不够充分。因此，本研究旨在进行系统评价和荟萃分析，为进一步研究治疗持续性和顽固性呃逆的替代治疗方案提供证据。
纳入符合顽固性呃逆诊断标准的>18 岁成年患者的随机对照试验（RCTs），无论性别、国籍和教育程度如何。将检索 8 个电子数据库，包括 4 个中文数据库（CNKI、SinoMed、万方数据库和中国科学期刊数据库）和 4 个英文数据库（Web of Science、Medline、Embase 和 Cochrane Library），从其建立日期到 2020 年 9 月。两名独立的综述作者将对每个 RCT 的标题摘要进行评估。如有分歧，将与第三位评论员讨论。使用 R-3.3.2 软件进行数据整合、异质性分析、亚组分析和敏感性分析。使用 RevMan 5.3 软件进行荟萃分析，并根据 Cochrane 手册 5.1 推荐的纳入试验的方法学质量进行“偏倚风险”评估。该研究的质量评价将由推荐评估、制定与评价（GRADE）完成。
本研究将总结所有旨在评估针刺以攒竹穴（BL2）为主的穴位治疗持续性和顽固性呃逆的有效性和安全性的选定试验。
本系统评价将提供评估针刺以攒竹穴（BL2）为主的穴位治疗持续性和顽固性呃逆的有效性和安全性的证据，这可能为临床医生在治疗这种疾病时提供更多选择。
PROSPERO 注册号：CRD42020114900。
