Ma Rui, Li Yan, Liu Songjiang, Zhao Wenhui
Department of Otolaryngology, the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine.
First affiliated Hospital, Heilongjiang University of Chinese Medicine.
Medicine (Baltimore). 2020 May;99(20):e19973. doi: 10.1097/MD.0000000000019973.
Hiccups are involuntary contractions of the diaphragm and intercostal muscles, which lead to sudden contractions of the glottis. CAM, such as acupuncture is commonly used and stimulation of the vagus nerve and interference with phrenic nerve conduction are also used to treat hiccups. However, there is little evidence on the effectiveness of acupuncture for cancer-related hiccups. We will plan to conduct a systematic review and meta-analysis of RCTs to evaluate the current evidence on the effects of acupuncture for cancer-related hiccups.
The following databases will be searched: PubMed, the Cochrane Library, Wanfang Data, China National Knowledge Infrastructure (CNKI), SinoMed, VIP, Medline, Embase, and EI. Randomized controlled trials will be included to evaluate the effect and safety of acupuncture on cancer patients with hiccups. We will set standards for the curative effect on the basis of the standard of cure and improvement for clinical disease diagnoses. The risk of bias will be assessed by the Cochrane risk of bias tool. We will conduct a meta-analysis and sensitivity analysis, as well as a subgroup analysis if high heterogeneity is present, using Revman 5.3. We will use funnel plots to identify potential reporting biases. We will test asymmetry using Egger test. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) will be used to evaluate the quality of evidence.
This study will be to assess the effect and safety of acupuncture for cancer-related hiccups.
This study will assess the effect of acupuncture for cancer-related hiccups and provide reliable evidence for the choice of treatments.
打嗝是膈肌和肋间肌的不自主收缩，会导致声门突然收缩。补充替代医学（CAM），如针灸，是常用的治疗方法，刺激迷走神经和干扰膈神经传导也用于治疗打嗝。然而，关于针灸治疗癌症相关性打嗝有效性的证据很少。我们计划对随机对照试验进行系统评价和荟萃分析，以评估目前关于针灸治疗癌症相关性打嗝效果的证据。
将检索以下数据库：PubMed、Cochrane图书馆、万方数据、中国知网（CNKI）、中国生物医学文献数据库（SinoMed）、维普资讯（VIP）、医学在线数据库（Medline）、荷兰医学文摘数据库（Embase）和工程索引数据库（EI）。将纳入随机对照试验，以评估针灸对癌症打嗝患者的疗效和安全性。我们将根据临床疾病诊断的治愈和改善标准制定疗效标准。将使用Cochrane偏倚风险工具评估偏倚风险。我们将使用Revman 5.3进行荟萃分析和敏感性分析，如果存在高度异质性，还将进行亚组分析。我们将使用漏斗图识别潜在的报告偏倚。我们将使用Egger检验测试不对称性。将采用推荐意见分级、评估与发展（GRADE）系统来评估证据质量。
本研究旨在评估针灸治疗癌症相关性打嗝的疗效和安全性。
本研究将评估针灸治疗癌症相关性打嗝的效果，并为治疗选择提供可靠证据。
