Zhang Ying, Zeng Jianfei, Wu Dan, Li Xiujuan, Chen Yangxia, Dai Shixia, Wang Bing, Qi Yu, Lu Jianping
Department of Child Psychiatry.
Shenzhen Kangning Hospital and Shenzhen Mental Health Center, Shenzhen, Guangdong Province, China.
Medicine (Baltimore). 2021 Mar 19;100(11):e22269. doi: 10.1097/MD.0000000000022269.
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition, which is characterized by impairment in social interaction or communication and lack of flexibility of imagination and behavior. Acupuncture is one of the most common modality of Traditional Chinese medicine (TCM) and has been used to treat various disease in clinical practice for more than 2000 years in China by correcting disharmony and dysregulation of body. It has sometimes been used as a treatment aimed at improving ASD symptoms and outcomes, but its clinical effectiveness and safety has not been rigorously reviewed. We will plan to conduct a systematic review and meta-analysis to summarize the current evidence on the effects and safety of acupuncture for ASD.
The following databases will be searched: PubMed, the Cochrane Library, Embase, Wanfang Data, China National Knowledge Infrastructure, SinoMed, and VIP. Randomised controlled trials will be included to evaluate the effect and safety of acupuncture on patients with ASD. The primary outcome will be the core features of ASD. The risk of bias will be assessed by the Cochrane risk of bias tool. We will conduct a meta-analysis and sensitivity analysis, as well as a subgroup analysis if high heterogeneity is present, using Revman 5.3. We will use funnel plots to identify potential reporting biases. The Grading of Recommendations Assessment, Development and Evaluation will be used to evaluate the quality of evidence.
This study will be to assess the effect and safety of acupuncture for ASD.
This study will assess the effect of acupuncture for ASD and provide reliable evidence for the choice of treatments.
The protocol will not need ethical approval because no issues of participant privacy exist. The results of this systematic review will provide evidence about the effect and safety of acupuncture for ASD. The results will be disseminated through peer review.
自闭症谱系障碍（ASD）是一种复杂的神经发育疾病，其特征是社交互动或沟通受损，以及想象力和行为缺乏灵活性。针灸是中医最常用的治疗方法之一，在中国临床实践中已用于治疗各种疾病两千多年，通过纠正身体的失调和紊乱来发挥作用。针灸有时被用作改善ASD症状和预后的一种治疗方法，但其临床有效性和安全性尚未得到严格审查。我们计划进行一项系统评价和荟萃分析，以总结目前关于针灸治疗ASD的效果和安全性的证据。
将检索以下数据库：PubMed、Cochrane图书馆、Embase、万方数据、中国知网、中国生物医学文献数据库和维普资讯。将纳入随机对照试验，以评估针灸对ASD患者的疗效和安全性。主要结局将是ASD的核心特征。将采用Cochrane偏倚风险工具评估偏倚风险。我们将使用Revman 5.3进行荟萃分析和敏感性分析，如果存在高度异质性，还将进行亚组分析。我们将使用漏斗图来识别潜在的报告偏倚。将采用推荐分级评估、制定与评价方法来评估证据质量。
本研究将评估针灸治疗ASD的疗效和安全性。
本研究将评估针灸治疗ASD的效果，并为治疗选择提供可靠证据。
该方案无需伦理批准，因为不存在参与者隐私问题。本系统评价的结果将提供关于针灸治疗ASD的效果和安全性的证据。结果将通过同行评审进行传播。
