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脂质体药物递送系统在口腔医学中的研究进展

[Research progress of liposome drug delivery system in stomatology].

作者信息

Hu Z M, Liu S Y, Yang H Y, Huang C

机构信息

The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School of Stomatology, Wuhan University, Wuhan 430079, China.

出版信息

Zhonghua Kou Qiang Yi Xue Za Zhi. 2021 Mar 9;56(3):294-300. doi: 10.3760/cma.j.cn112144-20200627-00372.

Abstract

Liposomes are spherical vesicles with bilayer membrane structure spontaneously formed by phospholipids dispersed in an aqueous medium. Liposomes are excellent drug carrier with amphiphilic properties. Liposomes have good biocompatibility, biodegradability and no immunogenicity. Liposomes can achieve the delivery of the drug, enhance the solubility, improve the stability, reduce the toxic effect of the drug, and improve the therapeutic effect of the loaded drug. In recent years, liposome drug delivery systems have been widely used in dentistry. This article reviews the application of liposome drug delivery systems in caries, dental pulp diseases, periodontitis, implantation, oral anesthesia and oral candidiasis.

摘要

脂质体是由分散在水介质中的磷脂自发形成的具有双层膜结构的球形囊泡。脂质体是具有两亲性的优良药物载体。脂质体具有良好的生物相容性、生物降解性且无免疫原性。脂质体能够实现药物递送,提高溶解度,改善稳定性,降低药物的毒性作用,并提高所载药物的治疗效果。近年来,脂质体药物递送系统已在牙科中广泛应用。本文综述了脂质体药物递送系统在龋齿、牙髓疾病、牙周炎、种植、口腔麻醉和口腔念珠菌病中的应用。

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