A new dibenzofuran derivative from the stem bark of with anti-inflammatory and cytotoxic activities.

The phytochemical investigation of the dichloromethane/methanol (1:1) extract of the stem bark of , led to the isolation of one new dibenzofuran derivative, named scyphocephalione A (), along with three other compounds, including epicatechin (), gentisic acid () and myo-inositol (). The structures of all the compounds were established with help of spectroscopic data including IR, UV, MS, 1 D- and 2 D-NMR, as well as by comparison with previously reported data in literature, and chemical modification. All the compounds were obtained from the genus for the first time. The anti-inflammatory activity (using chemiluminescence technique) of the crude extract and compound , together with NO inhibition (using ELISA), TNF-α (using ELISA) and MCF-7 cells cytotoxicity effects (using MTT assay) of compound were assessed. From the results obtained, compound could be considered as a promising chemotherapeutic agent for the treatment of inflammatory diseases.