Sun Zhi-Gang, Li Zhi-Na, Miao Xiang-Wan, Li Shuang, Zhu Hai-Liang
Central Laboratory, Linyi Central Hospital, No.17 Jiankang Road, Linyi 276400, China.
Department of Otorhinolaryngology-Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510000, China.
Mini Rev Med Chem. 2021;21(14):1888-1908. doi: 10.2174/1389557521666210304110824.
Virus is a type of noncellular organism, which is simple in structure, small in size and contains only one kind of nucleic acid (RNA or DNA). It must be parasitized in living cells and proliferates by replication. Viruses can infect plants or animals, which leads to many epidemic diseases, such as the current pandemic COVID-19. Viral infectious diseases have brought serious threats to the health of people around the world. Natural products are chemical substances that are usually produced by living organisms and have biological or pharmacological activity. Many of these natural products show antiviral activity. Based on the increasing importance of antiviral research, this paper focuses on the discovery and development of antiviral natural products since 2010.
病毒是一种非细胞生物，其结构简单，体积微小，仅含有一种核酸（RNA或DNA）。它必须寄生在活细胞中，并通过复制进行增殖。病毒可感染植物或动物，从而引发许多流行病，如当前的全球大流行疾病COVID-19。病毒性传染病对全球人民的健康构成了严重威胁。天然产物是通常由生物体产生并具有生物或药理活性的化学物质。这些天然产物中的许多都显示出抗病毒活性。基于抗病毒研究日益增加的重要性，本文重点关注2010年以来抗病毒天然产物的发现与开发。
