Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ain-Helwan, Helwan, Cairo, Egypt.
Med Chem. 2022;18(2):238-248. doi: 10.2174/1573406417666210304100830.
Thiobezimidazoles reveal various pharmacological activities due to similarities with many natural and synthetic molecules; they can easily interact with biomolecules of living systems.
A series of substituted 2-thiobezimidazoles have been synthesized. Twelve final compounds were screened for in vitro anti-cancer activities against sixty different cell lines.
The spectral data of the synthesized compounds were characterized. A docking study for active anticancer compounds and CDK2/CyclinA2 Kinase assay against standard reference; Imatinib, were performed.
Two compounds (3c&3l) from the examined series revealed effective antitumor activity in vitro against two-cancer cell lines (Colon Cancer (HCT-116) and Renal Cancer (TK-10). The docking study of synthesized molecules discovered a requisite binding pose in the CDK-ATP binding pocket .3c &3l were promoted in the CDK2/CyclinA2 Kinase assay against standard reference Imatinib.
Against all tested compounds; two compounds 3c &3l were found active against two types of cell-lines.
噻唑并咪唑类由于与许多天然和合成分子相似，具有多种药理活性；它们可以很容易地与生命系统的生物分子相互作用。
合成了一系列取代的 2-噻唑并咪唑类化合物。对 60 种不同细胞系进行了 12 种终化合物的体外抗癌活性筛选。
对合成化合物的光谱数据进行了表征。对活性抗癌化合物进行对接研究，并对标准参考物 CDK2/CyclinA2 激酶进行了测定；伊马替尼。
在所检查的系列中，有两种化合物（3c 和 3l）在体外对两种癌细胞系（结肠癌细胞（HCT-116）和肾癌细胞（TK-10））显示出有效的抗肿瘤活性。对合成分子的对接研究发现，在 CDK-ATP 结合口袋中存在必需的结合构象。3c 和 3l 在针对标准参考物伊马替尼的 CDK2/CyclinA2 激酶测定中得到了促进。
在所有测试的化合物中，有两种化合物 3c 和 3l 对两种类型的细胞系表现出活性。
