Zhang Qian, Liang Xiao Chun
Department of Traditional Chinese Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2021 Feb 28;43(1):124-129. doi: 10.3881/j.issn.1000-503X.11477.
Diabetic peripheral neuropathy(DPN),a chronic diabetic microvascular complication with a high incidence among diabetic patients,increases the risk of diabetic foot and amputation.Many methods are available for screening and evaluating DPN,including traditional 10 g monofilament,tuning fork and vibration perception,and tendon reflex tests,which should be combined with some nerve function score systems to improve the detection rate and accuracy for DPN.In recent years,a number of noninvasive new techniques have been developed for the evaluation of nerve injury,such as corneal confocal microscopy,quantitative sensory testing,current perception threshold test,sympathetic sudomotor function evaluation,and quantitative detection of skin advanced glycation end products.This paper reviews these noninvasive methods for screening and evaluating DPN to help clinicians detect and focus on DPN early.
糖尿病周围神经病变（DPN）是糖尿病患者中发病率较高的一种慢性糖尿病微血管并发症，它会增加糖尿病足和截肢的风险。有许多方法可用于筛查和评估DPN，包括传统的10克单丝检查、音叉和振动觉检查以及腱反射测试，这些方法应与一些神经功能评分系统相结合，以提高DPN的检出率和准确性。近年来，已开发出一些用于评估神经损伤的非侵入性新技术，如角膜共焦显微镜检查、定量感觉测试、电流感觉阈值测试、交感神经汗腺运动功能评估以及皮肤晚期糖基化终产物的定量检测。本文综述了这些用于筛查和评估DPN的非侵入性方法，以帮助临床医生早期发现并关注DPN。
