Kuper C F, Reuzel P G, Feron V J, Verschuuren H
TNO-CIVO Toxicology and Nutrition Institute, Zeist, The Netherlands.
Food Chem Toxicol. 1988 Feb;26(2):159-67. doi: 10.1016/0278-6915(88)90112-3.
Four groups of 100 Wistar rats of each sex were exposed by inhalation to 0, 30, 100 or 300 ppm propylene oxide for 6 hr/day, 5 days/wk for 28 months. After 12, 18 and 24 months ten rats/sex/group were killed to provide interim haematological, biochemical and urinary data. Mortality was increased by wk 115 in both sexes in the 300-ppm group and by wk 119 in females of the 100-ppm group. Body weights were lower than those of the controls throughout the study in males of the 300-ppm group and in females of the 300-ppm group during the first year of the study. Increased incidences of degenerative and hyperplastic changes of the nasal mucosa were observed in all exposed groups. Exposure to 300 ppm propylene oxide was associated with an increased incidence of both benign and malignant mammary tumours in females. There was no increase in the incidence of any particular type of tumour other than mammary tumours. The total number of rats bearing malignant tumours at sites other than the mammary glands was increased in both sexes in the 300-ppm group compared with the controls.
将四组每组100只不同性别的Wistar大鼠通过吸入方式暴露于浓度为0、30、100或300 ppm的环氧丙烷环境中，每天暴露6小时，每周暴露5天，持续28个月。在第12、18和24个月时，每组按性别处死10只大鼠，以获取中期血液学、生物化学和尿液数据。在300 ppm组中，两性在第115周时死亡率增加；在100 ppm组中，雌性在第119周时死亡率增加。在整个研究过程中，300 ppm组的雄性大鼠以及在研究的第一年中300 ppm组的雌性大鼠体重均低于对照组。在所有暴露组中均观察到鼻粘膜退行性和增生性变化的发生率增加。暴露于300 ppm环氧丙烷会使雌性良性和恶性乳腺肿瘤的发生率增加。除乳腺肿瘤外，其他任何特定类型肿瘤的发生率均未增加。与对照组相比，300 ppm组两性中乳腺以外部位出现恶性肿瘤的大鼠总数增加。
