Feron V J, Woutersen R A, van Garderen-Hoetmer A, Dreef-van der Meulen H C
TNO-CIVO Toxicology and Nutrition Institute, Zeist, The Netherlands.
Environ Health Perspect. 1990 Apr;85:305-15. doi: 10.1289/ehp.85-1568344.
A survey is given of upper respiratory tract tumors in Cpb:WU (Wistar random) rats. Data were collected from ten 24- to 30-month toxicity/carcinogenicity studies and from one 12-month study. Nasal tumors may lead to dyspnea, mouth breathing, and nasal discharge. These clinical signs mainly occurred in rats bearing squamous cell carcinomas. The large nasal tumors were often osteolytic, they invaded the subcutis over the premaxilla, resulting in swellings on the back of the nose, and extended into the brain. The incidence of nasal tumors in untreated male controls was 1.1% (7/661), the tumors invariably being squamous cell carcinomas. There were no nasal tumors found in untreated female controls. The type of compound-induced nasal tumor most frequently observed was adenocarcinoma (of the olfactory epithelium) followed, in order of decreasing incidence, by squamous cell carcinoma, carcinoma in situ, polypoid adenoma, Schwannoma, and carcinosarcoma. It was proposed that adenocarcinomas of the olfactory epithelium should be classified as neuroepitheliomas. It was also suggested that squamous cell carcinomas, seen in association with necrotizing inflammation of an incisor tooth, should be considered as part of the malocclusion syndrome. No spontaneous tracheal tumors were observed, and only one out of 422 untreated female controls (0.2%) was seen to have a laryngeal tumor, an adenoma. Induced laryngeal tumors included carcinoma in situ, squamous cell carcinoma, and adenocarcinoma. Squamous cell carcinoma was the only type of treatment-related tracheal tumor found. The incidences of induced laryngeal and tracheal tumors were very low, and in no case were these tumors statistically significantly different from the respective incidences in controls.
对Cpb:WU（Wistar随机）大鼠的上呼吸道肿瘤进行了一项调查。数据收集自十项24至30个月的毒性/致癌性研究以及一项12个月的研究。鼻肿瘤可能导致呼吸困难、张口呼吸和鼻分泌物增多。这些临床症状主要出现在患有鳞状细胞癌的大鼠中。大的鼻肿瘤通常具有溶骨性，它们侵犯上颌前部的皮下组织，导致鼻背部肿胀，并延伸至脑部。未处理的雄性对照大鼠中鼻肿瘤的发生率为1.1%（7/661），这些肿瘤均为鳞状细胞癌。未处理的雌性对照大鼠中未发现鼻肿瘤。最常观察到的化合物诱导性鼻肿瘤类型是腺癌（嗅上皮），其次按发病率递减顺序依次为鳞状细胞癌、原位癌、息肉状腺瘤、施万细胞瘤和癌肉瘤。有人提议将嗅上皮腺癌归类为神经上皮瘤。还建议将与切牙坏死性炎症相关的鳞状细胞癌视为错牙合综合征的一部分。未观察到自发性气管肿瘤，在422只未处理的雌性对照大鼠中仅1只（0.2%）出现喉部肿瘤，为腺瘤。诱导性喉部肿瘤包括原位癌、鳞状细胞癌和腺癌。鳞状细胞癌是唯一发现的与治疗相关的气管肿瘤类型。诱导性喉部和气管肿瘤的发生率非常低，且在任何情况下这些肿瘤与对照大鼠各自的发生率在统计学上均无显著差异。
