FD&C 黄色 5 号（柠檬黄）对小鼠的慢性毒性/致癌性研究。

A chronic toxicity/carcinogenicity study of FD & C Yellow No. 5 (tartrazine) in mice.

作者信息

Borzelleca J F, Hallagan J B

机构信息

Medical College of Virginia, Department of Pharmacology and Toxicology, Richmond 23298.

出版信息

Food Chem Toxicol. 1988 Mar;26(3):189-94. doi: 10.1016/0278-6915(88)90118-4.

DOI:10.1016/0278-6915(88)90118-4

PMID:3366419

Abstract

Charles River CD-1 mice were fed FD & C Yellow No. 5 in the diet at levels of 0.0, 0.0, 0.5, 1.5 or 5.0% in a long-term toxicity/carcinogenicity study. Each group consisted of 60 males and 60 females. Maximum exposure was 104 wk for both males and females. No consistent, significant compound-related adverse effects were noted. The no-observed-adverse effect level established in this study was 5.0% (8103 mg/kg/day and 9735 mg/kg/day for male and female mice, respectively.)

摘要

在一项长期毒性/致癌性研究中，给查尔斯河CD-1小鼠喂食含有0.0%、0.0%、0.5%、1.5%或5.0%亮蓝的饲料。每组由60只雄性和60只雌性小鼠组成。雄性和雌性小鼠的最大暴露时间均为104周。未观察到与化合物相关的一致且显著的不良反应。本研究确定的未观察到不良反应水平为5.0%（雄性和雌性小鼠分别为8103毫克/千克/天和9735毫克/千克/天）。