Ershoff B H
J Nutr. 1977 May;107(5):822-8. doi: 10.1093/jn/107.5.822.
Tests were conducted on the effects of diet on the response of immature male rats to massive doses of tartrazine (FD&C Yellow No.5) and Sunset Yellow FCF (FD&C Yellow No. 6). When incorporated at a 5% level in a stock diet, tartrazine and Sunset Yellow FCF had no grossly observable toxic effects. When fed with a purified diet, however, both tartrazine and Sunset Yellow FCF at 5% level in the diet resulted in a marked retardation in growth, an unthrifty appearance of the fur and death of 50% or more of the rats within an experimental period of 14 days. The toxic effects obtained by feeding the latter diets were counteracted by the concurrent feeding of blond psyllium seed powder, carrot root powder, alfalfa leaf meal and wheat bran. Supplements of the known nutrients had little if any protective effect. Supplements of purified cellulose were without protective effect for the rats fed tartrazine but had a moderate protective effect for those fed Sunset Yellow FCF.
针对饮食对未成熟雄性大鼠对大剂量柠檬黄（FD&C 黄色 5 号）和日落黄 FCF（FD&C 黄色 6 号）反应的影响进行了测试。当在基础日粮中以 5% 的水平添加时，柠檬黄和日落黄 FCF 没有明显可见的毒性作用。然而，当用纯化日粮喂养时，日粮中 5% 水平的柠檬黄和日落黄 FCF 都会导致生长明显迟缓、皮毛外观不佳，并且在 14 天的实验期内 50% 或更多的大鼠死亡。同时喂食金色车前草籽粉、胡萝卜根粉、苜蓿叶粉和麦麸可抵消喂食后一种日粮所产生的毒性作用。补充已知营养素几乎没有保护作用。纯化纤维素补充剂对喂食柠檬黄的大鼠没有保护作用，但对喂食日落黄 FCF 的大鼠有一定的保护作用。
