Zhang Rui, Meng Jingjing, Lian Qinshu, Chen Xi, Bauman Brent, Chu Haitao, Segura Bradley, Roy Sabita
College of Pharmacy, University of Minnesota, Minneapolis, MN, United States of America.
Institute for Health Informatics, University of Minnesota, Minneapolis, MN, United States of America.
PLoS One. 2018 Jan 2;13(1):e0190362. doi: 10.1371/journal.pone.0190362. eCollection 2018.
Sepsis continues to be a major problem for hospitalized patients. Opioids are widely used medications for pain management despite recent evidence revealing their adverse effects. The present study evaluates survival differences between opioid-treated patients and non-opioid-treated patients hospitalized with a diagnosis of sepsis. Clinical data was extracted from the University of Minnesota's Clinical Data Repository, which includes Electronic Health Records (EHRs) of the patients seen at 8 hospitals. Among 5,994 patients diagnosed with sepsis, 4,540 opioid-treated patients and 1,454 non-opioid patients were included based on whether they are exposed to prescription opioids during their hospitalization. Cox proportional hazards regression showed that after adjustments for demographics, clinical comorbidities, severity of illness, and types of infection, opioid-treated patients had a significantly higher risk of death at 28 days.
脓毒症仍然是住院患者面临的一个主要问题。尽管最近有证据表明阿片类药物存在不良反应，但它们仍是广泛用于疼痛管理的药物。本研究评估了因脓毒症诊断而住院的阿片类药物治疗患者和非阿片类药物治疗患者之间的生存差异。临床数据取自明尼苏达大学的临床数据存储库，其中包括8家医院患者的电子健康记录（EHR）。在5994例诊断为脓毒症的患者中，根据他们在住院期间是否接触过处方阿片类药物，纳入了4540例阿片类药物治疗患者和1454例非阿片类药物治疗患者。Cox比例风险回归分析表明，在对人口统计学、临床合并症、疾病严重程度和感染类型进行调整后，阿片类药物治疗患者在28天时的死亡风险显著更高。
