Fellbaum C, Hansmann M L, Lennert K
Department of Pathology, Christian-Albrecht University, Kiel, FRG.
Histopathology. 1988 Mar;12(3):253-62. doi: 10.1111/j.1365-2559.1988.tb01940.x.
A variant of lymphadenitis mimicking interfollicular Hodgkin's disease is described. The morphology, immunohistochemistry and clinical course of 25 cases are reported. The morphology is characterized by changes in the interfollicular region within a well-preserved lymph node architecture. These changes include variegated hyperplasia of the pulp with epithelioid cells, mature eosinophilic granulocytes and immunoblasts occasionally resembling Hodgkin cells. In contrast to Hodgkin's disease no typical Sternberg-Reed cells could be found. Immunohistochemically, neither positive reactions with Hodgkin cell markers (anti-CD15: LeuM1; 3C4; C3D-1) nor B-cell monoclonality could be detected. Transition to malignancy, in particular Hodgkin's disease, did not occur in our cases.
本文描述了一种酷似滤泡间霍奇金病的淋巴结炎变体。报告了25例患者的形态学、免疫组化及临床病程。形态学特征为保存完好的淋巴结结构内滤泡间区域发生改变。这些改变包括髓质的斑驳状增生，伴有上皮样细胞、成熟嗜酸性粒细胞及偶尔类似霍奇金细胞的免疫母细胞。与霍奇金病不同，未发现典型的施特恩贝格-里德细胞。免疫组化显示，既未检测到霍奇金细胞标志物（抗CD15：LeuM1；3C4；C3D-1）的阳性反应，也未检测到B细胞单克隆性。在我们的病例中未发生向恶性肿瘤的转变，尤其是霍奇金病。
