Loss of autophagy affects melanoma development in a manner dependent on PTEN status.
作者信息
Rosenfeldt Mathias T, O'Prey Jim, Lindsay Colin R, Nixon Colin, Roth Sabine, Sansom Owen J, Ryan Kevin M
机构信息
Cancer Research UK Beatson Institute, Glasgow, UK.
Comprehensive Cancer Center Mainfranken, Wuerzburg, Germany.
出版信息
Cell Death Differ. 2021 Apr;28(4):1437-1439. doi: 10.1038/s41418-021-00746-7. Epub 2021 Mar 4.
Abstract
摘要
相似文献
1
Loss of autophagy affects melanoma development in a manner dependent on PTEN status.自噬缺失以依赖于PTEN状态的方式影响黑色素瘤的发展。
Cell Death Differ. 2021 Apr;28(4):1437-1439. doi: 10.1038/s41418-021-00746-7. Epub 2021 Mar 4.
2
Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma.自噬相关蛋白7（Atg7）克服衰老并促进BRAF V600E驱动的黑色素瘤生长。
Cancer Discov. 2015 Apr;5(4):410-23. doi: 10.1158/2159-8290.CD-14-1473. Epub 2015 Feb 11.
3
Complete loss of PTEN protein expression correlates with shorter time to brain metastasis and survival in stage IIIB/C melanoma patients with BRAFV600 mutations.PTEN蛋白表达完全缺失与BRAFV600突变的IIIB/C期黑色素瘤患者发生脑转移的时间缩短及生存期相关。
Clin Cancer Res. 2014 Nov 1;20(21):5527-36. doi: 10.1158/1078-0432.CCR-14-1027. Epub 2014 Aug 27.
4
WNT/β-catenin signaling regulates mitochondrial activity to alter the oncogenic potential of melanoma in a PTEN-dependent manner.WNT/β-连环蛋白信号通路以磷酸酶与张力蛋白同源物（PTEN）依赖的方式调节线粒体活性，从而改变黑色素瘤的致癌潜能。
Oncogene. 2017 Jun 1;36(22):3119-3136. doi: 10.1038/onc.2016.450. Epub 2017 Jan 16.
5
Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss.在由NF1/PTEN缺失驱动的高危肿瘤中，通过抑制MCL1和BCL2介导的协同性黑色素瘤细胞死亡。
Oncogene. 2021 Sep;40(38):5718-5729. doi: 10.1038/s41388-021-01926-y. Epub 2021 Jul 30.
6
PTEN Methylation Dependent Sinonasal Mucosal Melanoma.PTEN 甲基化依赖型鼻腔鼻窦黏膜黑色素瘤。
Cancer Res Treat. 2016 Apr;48(2):853-8. doi: 10.4143/crt.2014.356. Epub 2015 Mar 18.
7
AXL/AKT axis mediated-resistance to BRAF inhibitor depends on PTEN status in melanoma.AXL/AKT 轴介导的 BRAF 抑制剂耐药性取决于黑色素瘤中的 PTEN 状态。
Oncogene. 2018 Jun;37(24):3275-3289. doi: 10.1038/s41388-018-0205-4. Epub 2018 Mar 19.
8
Inhibition of autophagy induced by PTEN loss promotes intrinsic breast cancer resistance to trastuzumab therapy.PTEN缺失诱导的自噬抑制促进了乳腺癌对曲妥珠单抗治疗的内在抗性。
Tumour Biol. 2016 Apr;37(4):5445-54. doi: 10.1007/s13277-015-4392-0. Epub 2015 Nov 12.
9
Revisiting the Clinical and Biologic Relevance of Partial PTEN Loss in Melanoma.重新探讨黑色素瘤中部分 PTEN 缺失的临床和生物学相关性。
J Invest Dermatol. 2019 Feb;139(2):430-438. doi: 10.1016/j.jid.2018.07.031. Epub 2018 Aug 24.
10
In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma.在致癌性 BRAF 诱导的黑色素瘤小鼠模型中体内鉴定肿瘤抑制性 PTEN ceRNAs。
Cell. 2011 Oct 14;147(2):382-95. doi: 10.1016/j.cell.2011.09.032.
引用本文的文献
1
The role of non-coding RNAs in the regulation of cell death pathways in melanoma.非编码RNA在黑色素瘤细胞死亡途径调控中的作用
Discov Oncol. 2025 Jun 11;16(1):1063. doi: 10.1007/s12672-025-02888-3.
2
Distinct Types of Regulated Cell Death in Melanoma.黑色素瘤中不同类型的程序性细胞死亡
Cells. 2025 Jun 1;14(11):823. doi: 10.3390/cells14110823.
3
The Role of Intermittent Fasting in the Activation of Autophagy Processes in the Context of Cancer Diseases.间歇性禁食在癌症疾病背景下自噬过程激活中的作用。
Int J Mol Sci. 2025 May 15;26(10):4742. doi: 10.3390/ijms26104742.
4
Emerging dimensions of autophagy in melanoma.黑色素瘤中自噬作用的新兴维度。
Autophagy. 2024 Aug;20(8):1700-1711. doi: 10.1080/15548627.2024.2330261. Epub 2024 Mar 21.
5
Autophagy Paradox: Strategizing Treatment Modality in Melanoma.自噬悖论：黑色素瘤治疗模式的策略制定。
Curr Treat Options Oncol. 2023 Feb;24(2):130-145. doi: 10.1007/s11864-023-01053-8. Epub 2023 Jan 21.
6
Metabolic rewiring directs melanoma immunology.代谢重编程指导黑色素瘤免疫学。
Front Immunol. 2022 Aug 8;13:909580. doi: 10.3389/fimmu.2022.909580. eCollection 2022.
7
ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis.ATG7 是肿瘤进展的杂合不足抑制剂和转移的促进剂。
Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2113465119. doi: 10.1073/pnas.2113465119. Epub 2022 Jul 6.
8
Co-Treatment of Chloroquine and Trametinib Inhibits Melanoma Cell Proliferation and Decreases Immune Cell Infiltration.氯喹和曲美替尼联合治疗可抑制黑色素瘤细胞增殖并减少免疫细胞浸润。
Front Oncol. 2022 Jun 30;12:782877. doi: 10.3389/fonc.2022.782877. eCollection 2022.
9
The multifaceted role of autophagy in cancer.自噬在癌症中的多方面作用。
EMBO J. 2022 Jul 4;41(13):e110031. doi: 10.15252/embj.2021110031. Epub 2022 May 10.
10
Signal pathways of melanoma and targeted therapy.黑色素瘤的信号通路与靶向治疗。
Signal Transduct Target Ther. 2021 Dec 20;6(1):424. doi: 10.1038/s41392-021-00827-6.
Zotero 插件