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与血吸虫病相关的表观遗传标记

Epigenetic Markers Associated with Schistosomiasis.

作者信息

Gomes Assenço R A, Alves Mota E, De Oliveira V F, De Castro Borges W, Guerra-Sá R

机构信息

Programa de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto. Ouro Preto, CEP 35400-000, Minas Gerais, Brazil.

Laboratório de Bioquímica e Biologia Molecular (LBBM), Departamento de Ciências Biológicas, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto. Ouro Preto, CEP 35400-000, Minas Gerais, Brazil.

出版信息

Helminthologia. 2021 Feb 10;58(1):28-40. doi: 10.2478/helm-2021-0009. eCollection 2021 Mar.

Abstract

It is important to consider the use of the epigenome as source of complementary data for genome knowledge, which is suitable for the diagnosis of schistosomiasis. Usually, a laboratory diagnosis of schistosomiasis is performed by means of . Egg detection in the stool or urine by microscopy remains with limited sensitivity; . Immunological screening, in which positivity persists after treatment, and . Molecular appraisals prevail over the disadvantages of the currently used methods. In this sense, molecular methodologies are being developed based on epigenetic biomarkers, aiming to improve the diagnosis of the disease and clinical treatment as early as possible to prevent the occurrence of serious liver damage.

摘要

将表观基因组作为基因组知识补充数据的来源加以考虑很重要,这适用于血吸虫病的诊断。通常,血吸虫病的实验室诊断通过以下方式进行:粪便或尿液中虫卵的显微镜检测,其敏感性有限;免疫筛查,治疗后仍呈阳性;以及分子评估,克服了当前所用方法的缺点。从这个意义上说,基于表观遗传生物标志物的分子方法正在开发中,旨在尽早改善疾病诊断和临床治疗,以防止严重肝损伤的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/754c/7912237/969b150e27fe/helm-58-028-g001.jpg

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