França Arthur S C, Borgesius Nils Z, Souza Bryan C, Cohen Michael X
Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, Netherlands.
Front Syst Neurosci. 2021 Feb 16;15:617388. doi: 10.3389/fnsys.2021.617388. eCollection 2021.
Novelty detection is a core feature of behavioral adaptation and involves cascades of neuronal responses-from initial evaluation of the stimulus to the encoding of new representations-resulting in the behavioral ability to respond to unexpected inputs. In the past decade, a new important novelty detection feature, beta2 (~20-30 Hz) oscillations, has been described in the hippocampus (HC). However, the interactions between beta2 and the hippocampal network are unknown, as well as the role-or even the presence-of beta2 in other areas involved with novelty detection. In this work, we combined multisite local field potential (LFP) recordings with novelty-related behavioral tasks in mice to describe the oscillatory dynamics associated with novelty detection in the CA1 region of the HC, parietal cortex, and mid-prefrontal cortex. We found that transient beta2 power increases were observed only during interaction with novel contexts and objects, but not with familiar contexts and objects. Also, robust theta-gamma phase-amplitude coupling was observed during the exploration of novel environments. Surprisingly, bursts of beta2 power had strong coupling with the phase of delta-range oscillations. Finally, the parietal and mid-frontal cortices had strong coherence with the HC in both theta and beta2. These results highlight the importance of beta2 oscillations in a larger hippocampal-cortical circuit, suggesting that beta2 plays a role in the mechanism for detecting and modulating behavioral adaptation to novelty.
新奇性检测是行为适应的核心特征，涉及一系列神经元反应——从对刺激的初始评估到新表征的编码——从而产生对意外输入做出反应的行为能力。在过去十年中，海马体（HC）中描述了一种新的重要新奇性检测特征，即β2（约20 - 30赫兹）振荡。然而，β2与海马网络之间的相互作用尚不清楚，β2在其他与新奇性检测相关的区域中的作用——甚至是否存在——也不清楚。在这项研究中，我们将多部位局部场电位（LFP）记录与小鼠的新奇性相关行为任务相结合，以描述与HC的CA1区域、顶叶皮质和前额叶中部皮质中的新奇性检测相关的振荡动力学。我们发现，仅在与新环境和新物体相互作用时观察到短暂的β2功率增加，而与熟悉的环境和物体相互作用时则未观察到。此外，在探索新环境期间观察到强大的θ-γ相位-幅度耦合。令人惊讶的是，β2功率爆发与δ波段振荡的相位有很强的耦合。最后，顶叶皮质和前额叶中部皮质在θ和β2波段与HC都有很强的相干性。这些结果突出了β2振荡在更大的海马-皮质回路中的重要性，表明β2在检测和调节对新奇性的行为适应机制中发挥作用。
