Walsh Callum, Tait Luke, Garrido Maria Garcia, Brown Jonathan T, Ridler Thomas
Hatherly Laboratories, Department of Clinical and Biomedical Sciences, University of Exeter Medical School, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK.
Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, CF24 4HQ, UK.
Sci Rep. 2025 Jan 23;15(1):2897. doi: 10.1038/s41598-025-86008-9.
Beta-frequency oscillations (20-30 Hz) are prominent in both human and rodent electroencephalogram (EEG) recordings. Discrete epochs of beta (or Beta2) oscillations are prevalent in the hippocampus and other brain areas during exploration of novel environments. However, little is known about the spatial distribution and temporal relationships of beta oscillations across the cortex in response to novel contexts. To investigate this, mice fitted with 30-channel EEG-style multi-electrode arrays underwent a single recording session in a novel environment. While changes to spectral properties of cortical oscillations were minimal, there was a profound increase in the rate of beta bursts during the initial part of the recording session, when the environment was most novel. This was true across the cortex but most notable in recording channels situated above the retrosplenial cortex. Additionally, novelty was associated with greater connectivity between retrosplenial areas and the rest of the cortex, specifically in the beta frequency range. However, it was also found that the cortex in general, is highly modulated by environmental novelty. This data further suggests the retrosplenial cortex is an important hub for distinguishing environmental context and highlights the diversity of functions for beta oscillations across the brain, which can be observed using high-density EEG.
β 频段振荡（20 - 30赫兹）在人类和啮齿动物的脑电图（EEG）记录中都很显著。在探索新环境期间，海马体和其他脑区普遍存在离散的β（或Beta2）振荡时期。然而，对于响应新环境时整个皮层中β振荡的空间分布和时间关系，我们知之甚少。为了研究这一点，给安装了30通道脑电图式多电极阵列的小鼠在新环境中进行了一次记录实验。虽然皮层振荡的频谱特性变化很小，但在记录实验的初始阶段，当环境最为新颖时，β 爆发的频率显著增加。整个皮层都是如此，但在脾后皮质上方的记录通道中最为明显。此外，新颖性与脾后区域和皮层其他部分之间更强的连通性有关，特别是在β 频率范围内。然而，研究还发现，一般来说，皮层受到环境新颖性的高度调节。这些数据进一步表明，脾后皮质是区分环境背景的重要枢纽，并突出了整个大脑中β振荡功能的多样性，这可以通过高密度脑电图观察到。
