Ferron Laurent, Koshti Saloni, Zamponi Gerald W
Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Neuronal Signal. 2021 Feb 23;5(1):NS20200095. doi: 10.1042/NS20200095. eCollection 2021 Apr.
Neuronal voltage-gated Ca (Ca) channels play a critical role in cellular excitability, synaptic transmission, excitation-transcription coupling and activation of intracellular signaling pathways. Ca channels are multiprotein complexes and their functional expression in the plasma membrane involves finely tuned mechanisms, including forward trafficking from the endoplasmic reticulum (ER) to the plasma membrane, endocytosis and recycling. Whether genetic or acquired, alterations and defects in the trafficking of neuronal Ca channels can have severe physiological consequences. In this review, we address the current evidence concerning the regulatory mechanisms which underlie precise control of neuronal Ca channel trafficking and we discuss their potential as therapeutic targets.
神经元电压门控钙（Ca）通道在细胞兴奋性、突触传递、兴奋-转录偶联以及细胞内信号通路激活中发挥关键作用。钙通道是多蛋白复合物，其在质膜上的功能表达涉及精细调控机制，包括从内质网（ER）向质膜的正向转运、内吞作用和再循环。无论是遗传性的还是后天获得性的，神经元钙通道转运的改变和缺陷都可能产生严重的生理后果。在本综述中，我们阐述了有关神经元钙通道转运精确控制背后调控机制的现有证据，并讨论了它们作为治疗靶点的潜力。
