Fraschini F, Scaglione F, Maierna G, Savio G, Gattei G, Falchi M
University of Milan, Italy.
Int J Clin Pharmacol Res. 1988;8(1):43-6.
The authors have proposed the evaluation of the possible pharmacokinetic interactions between xibornol and theophylline. This study has been carried out on eight healthy volunteers of both sexes between 19 and 27 years of age. On the first day each subject was treated with 600 mg oral sustained-release formulation of aminophylline at 08h00 and at 20h00. From the 2nd day an oral administration of 500 mg of xibornol every 8 h was added to the treatment of aminophylline. On the 1st, 2nd and 5th day blood samples were taken after 30, 90, 180 and 300 min following drug administration. After serum separation an analysis was performed on them. The results have shown that theophylline levels at the programmed times during the three days tested are just overlapping. In conclusion the administration of xibornol does not introduce any interference with theophylline clearance or lengthening of its plasma half-life.
作者们提议评估希波酚与茶碱之间可能存在的药代动力学相互作用。该研究在8名年龄在19至27岁之间的健康男女志愿者身上进行。第一天，每位受试者于08:00和20:00各服用600毫克氨茶碱口服缓释制剂。从第二天起，在氨茶碱治疗基础上，每8小时额外口服500毫克希波酚。在第1、2和5天，给药后30、90、180和300分钟采集血样。血清分离后对血样进行分析。结果表明，在测试的三天中，各设定时间的茶碱水平相互重叠。总之，服用希波酚不会对茶碱清除率或其血浆半衰期延长产生任何干扰。
