Cannizzaro G F, Pesce L, Zanoli P, Milani G F, Zannoni F, Pivirotto F
Department of Pneumonology, Unità Sanitaria Locale, Rovigo, Italy.
Int J Clin Pharmacol Res. 1988;8(1):37-41.
The authors studied serum theophylline levels after administration of new single-dose capsules: Teonova. Special attention was paid to possible fluctuations of serum theophylline after administration of the drug following a standardized meal. For this purpose a test was carried out on eight male patients with intrinsic asthma. The patients were given a dose able to produce a serum concentration of theophylline of between 10 mcg and 20 mcg at the tenth hour after the administration. This dose was found to be 400 mg (2 tablets of 200 mg) for one patient and 600 mg (2 tablets of 300 mg) for the remaining seven. The capsules of Teonova were administered to each patient for two subsequent days at 07h00. On the first day the patients had their capsules after fasting, and on the second day after a standardized meal. The test proved that Teonova assured a satisfactory serum theophylline level throughout the 24 hours in all patients; food in no way affected the absorption kinetics of the drug. Such features make Teonova suitable for long-term theophylline therapy.
作者研究了新型单剂量胶囊Teonova给药后的血清茶碱水平。特别关注了在标准餐后服用该药物后血清茶碱可能出现的波动情况。为此，对8名内源性哮喘男性患者进行了一项试验。给患者服用的剂量在给药后第10小时能使血清茶碱浓度达到10微克至20微克。发现该剂量对1名患者为400毫克（2片200毫克），对其余7名患者为600毫克（2片300毫克）。Teonova胶囊在随后两天的07:00给每位患者服用。第一天患者在空腹后服用胶囊，第二天在标准餐后服用。试验证明，Teonova在所有患者中24小时内都能确保血清茶碱水平令人满意；食物对药物的吸收动力学没有任何影响。这些特性使Teonova适用于长期茶碱治疗。
