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High prevalence of neutralizing antibodies after long-term botulinum neurotoxin therapy.长期肉毒毒素治疗后中和抗体的高发生率。
Neurology. 2019 Jan 1;92(1):e48-e54. doi: 10.1212/WNL.0000000000006688. Epub 2018 Nov 21.
2
Preoperative anxiety and associated factors among adult surgical patients in Debre Markos and Felege Hiwot referral hospitals, Northwest Ethiopia.埃塞俄比亚西北部德布雷马科斯和费莱格希沃特转诊医院成年外科患者的术前焦虑及相关因素
BMC Anesthesiol. 2018 Oct 30;18(1):155. doi: 10.1186/s12871-018-0619-0.
3
Influence on smile attractiveness of the smile arc in conjunction with gingival display.微笑弧与龈显露对微笑吸引力的影响。
Am J Orthod Dentofacial Orthop. 2013 Oct;144(4):541-7. doi: 10.1016/j.ajodo.2013.05.006.
4
Effect of the gingival display on posed smile with different facial forms: a comparison of dentists and patients concepts.牙龈暴露对不同面部形态下 posed 微笑的影响:牙医与患者观念的比较
Indian J Dent Res. 2012 Sep-Oct;23(5):568-73. doi: 10.4103/0970-9290.107328.
5
Immunogenicity of botulinum toxins.肉毒毒素的免疫原性。
J Neural Transm (Vienna). 2013 Feb;120(2):275-90. doi: 10.1007/s00702-012-0893-9. Epub 2012 Sep 25.
6
Meta-analysis of neutralizing antibody conversion with onabotulinumtoxinA (BOTOX®) across multiple indications.多适应证下注射用肉毒毒素(保妥适)中和抗体转阳的荟萃分析。
Mov Disord. 2010 Oct 15;25(13):2211-8. doi: 10.1002/mds.23254.
7
Botulinum toxin.肉毒杆菌毒素
Indian J Dermatol. 2010;55(1):8-14. doi: 10.4103/0019-5154.60343.
8
Effect of preoperative multimedia information on perioperative anxiety in patients undergoing procedures under regional anaesthesia.术前多媒体信息对接受区域麻醉下手术患者围手术期焦虑的影响。
Br J Anaesth. 2010 Mar;104(3):369-74. doi: 10.1093/bja/aeq002. Epub 2010 Feb 1.
9
Surface anatomy of the lip elevator muscles for the treatment of gummy smile using botulinum toxin.用于肉毒杆菌毒素治疗露龈笑的提唇肌表面解剖学
Angle Orthod. 2009 Jan;79(1):70-7. doi: 10.2319/091407-437.1.
10
Immunological aspects of Botox, Dysport and Myobloc/NeuroBloc.保妥适、丽舒妥和肉毒杆菌素/神经阻断剂的免疫学方面
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评估A型肉毒杆菌毒素(保妥适®)治疗露龈笑的效果及持久性——一项长达4年随访的纵向研究。

To evaluate the effect and longevity of Botulinum toxin type A (Botox®) in the management of gummy smile - A longitudinal study upto 4 years follow-up.

作者信息

Rajagopal Athreya, Goyal Manoj, Shukla Sagrika, Mittal Neeti

机构信息

Oral and maxillofacial surgeon, Sant Parmanand Hospital, Delhi, India.

Oral and maxillofacial surgery, Santosh University, Gaziabad, India.

出版信息

J Oral Biol Craniofac Res. 2021 Apr-Jun;11(2):219-224. doi: 10.1016/j.jobcr.2021.02.006. Epub 2021 Feb 10.

DOI:10.1016/j.jobcr.2021.02.006
PMID:33665071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7898180/
Abstract

AIM

the current study was aimed (1) To study the effect of Botulinum toxin (BT) A on gummy smile (2) To determine the efficacy, predictability & longevity of the effect of Botox® in the management of gummy smile and lastly (3)To identify the treatment groups for Botox® as a single modality for the non-surgical treatment of gummy smile.

MATERIAL AND METHOD

only patients who were willing to get the treatment done with Botox® injection were enrolled in the study, irrespective for the need for the surgery. Thus, total of 32 patients were divided into two groups, group 1, having a gummy smile with less than 5 ​mm who were treated with 3 units of Botox® and group II, having gummy smile of more than 5 ​mm who were treated with 5 units of Botox® and each group underwent 2 cycles of injection 7 months apart given at the Yonsei's point and were followed for a period of 14 months.

RESULTS

the procedure was tolerated well by the patients; none developed any allergic reaction or antibodies related to BT. In the less that 5 ​mm and more than 5 ​mm of gingival show group the results remain excellent till 3 months after which gummy smile gradually reaches to the baseline levels. Significant changes start to reappear by the 5th month.

CONCLUSION

Authors recommend use of BT for the treatment of gummy smile as the technique is safe, economical and easy to use. Though not long lasting, it may motivate patients to go for surgical procedure, mainly who have gummy smile of more than 5 ​mm because of maxillary vertical excess.

摘要

目的

本研究旨在(1)研究A型肉毒杆菌毒素(BT)对露龈笑的影响;(2)确定保妥适®治疗露龈笑的疗效、可预测性及效果持续时间;最后(3)确定保妥适®作为非手术治疗露龈笑单一方式的治疗组。

材料与方法

本研究仅纳入愿意接受保妥适®注射治疗的患者,无论其是否需要手术。因此,32例患者共分为两组,第一组为牙龈外露小于5毫米的露龈笑患者,接受3单位保妥适®治疗;第二组为牙龈外露大于5毫米的露龈笑患者,接受5单位保妥适®治疗。每组均在延世点进行2个周期的注射,间隔7个月,并随访14个月。

结果

患者对该治疗耐受性良好;均未出现任何与BT相关的过敏反应或抗体。在牙龈外露小于5毫米组和大于5毫米组,治疗效果在3个月内均保持极佳,之后露龈笑逐渐恢复至基线水平。显著变化在第5个月开始再次出现。

结论

作者推荐使用BT治疗露龈笑,因为该技术安全、经济且易于使用。尽管效果不持久,但它可能促使患者选择手术治疗,主要是那些因上颌垂直过长导致牙龈外露大于5毫米的患者。