淋巴细胞诱导的心脏收缩反应刺激。

Lymphocyte-induced stimulation of the contractile response of the heart.

作者信息

Fink S B, Finiasz M, Sterin-Borda L, Borda E, de Bracco M M

机构信息

Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.

出版信息

Int J Immunopharmacol. 1988;10(1):53-7. doi: 10.1016/0192-0561(88)90150-6.

DOI:10.1016/0192-0561(88)90150-6

PMID:3366509

Abstract

In previous reports we have shown that phytohemagglutinin (PHA)-activated human lymphocytes had positive inotropic effects on spontaneously beating isolated rat atria. In this study, we demonstrated that the stimulatory effect on heart contractility induced by lymphocytes was linked to early events of lymphocyte activation by lectins. Active soluble factors were gradually released to the fluid phase. Similar results were obtained with both mitogenic (PHA) and nonmitogenic (WGA) lectins indicating that the stimulatory action of activated lymphocytes did not require cell division. Absence of Ca2+ inhibited both the generation of the stimulatory activity and lymphocyte proliferation. In contrast, verapamil, dexamethasone and low concentrations of cycloheximide eliminated only the appearance of the stimulatory effect.

摘要

在先前的报告中，我们已经表明，植物血凝素（PHA）激活的人淋巴细胞对自发搏动的离体大鼠心房具有正性肌力作用。在本研究中，我们证明淋巴细胞对心脏收缩力的刺激作用与凝集素激活淋巴细胞的早期事件有关。活性可溶性因子逐渐释放到液相中。促有丝分裂（PHA）和非促有丝分裂（WGA）凝集素均得到了类似结果，表明活化淋巴细胞的刺激作用并不需要细胞分裂。Ca2+ 的缺失抑制了刺激活性的产生以及淋巴细胞增殖。相比之下，维拉帕米、地塞米松和低浓度的环己酰亚胺仅消除了刺激作用的出现。