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库欣病患者股骨远端自发性骨梗死:一例报告

Spontaneous bone infarction of the distal femur in a patient with Cushing's disease: a case report.

作者信息

van Houten Pepijn, de Rooy Jacky, van der Geest Ingrid, Netea-Maier Romana, van de Ven Annenienke

机构信息

Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Centre, Nijmegen, the Netherlands.

Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands.

出版信息

Bone Rep. 2021 Feb 18;14:100756. doi: 10.1016/j.bonr.2021.100756. eCollection 2021 Jun.

DOI:10.1016/j.bonr.2021.100756
PMID:33665239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7905338/
Abstract

Avascular necrosis of the femoral head is a well-known complication of treatment with high dosage glucocorticoids and has been described in a few patients with Cushing's syndrome. In this case report, we describe the, to our knowledge, first case of a patient with endogenous Cushing's syndrome with a bone infarction located in the distal femur. In patients with Cushing's syndrome and bone pain, the diagnosis of bone infarction should be considered as it can occur as a rare complication of hypercortisolism.

摘要

股骨头缺血性坏死是高剂量糖皮质激素治疗的一种众所周知的并发症,并且在少数库欣综合征患者中已有描述。在本病例报告中,据我们所知,我们描述了首例患有内源性库欣综合征且股骨远端发生骨梗死的患者。对于患有库欣综合征且伴有骨痛的患者,应考虑骨梗死的诊断,因为它可能是皮质醇增多症的一种罕见并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bef3/7905338/68ecf750cdd3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bef3/7905338/3935cd0b6712/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bef3/7905338/68ecf750cdd3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bef3/7905338/3935cd0b6712/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bef3/7905338/68ecf750cdd3/gr2.jpg

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本文引用的文献

1
Avascular necrosis of the femoral head: An exceptional complication of cushing's disease.股骨头缺血性坏死:库欣病的一种罕见并发症。
Ann Afr Med. 2018 Oct-Dec;17(4):225-227. doi: 10.4103/aam.aam_75_17.
2
Oral glucocorticoid use and osteonecrosis in children and adults with chronic inflammatory diseases: a population-based cohort study.慢性炎症性疾病儿童和成人使用口服糖皮质激素与骨坏死:一项基于人群的队列研究。
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Vascular Health in Patients in Remission of Cushing's Syndrome Is Comparable With That in BMI-Matched Controls.
接受髋关节置换术多种激素替代疗法的患者:如何排除干扰并专注治疗?
Cureus. 2022 Aug 11;14(8):e27904. doi: 10.7759/cureus.27904. eCollection 2022 Aug.
库欣综合征缓解期患者的血管健康状况与体重指数匹配的对照组相当。
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Spontaneous resolution of avascular necrosis of femoral heads following cure of Cushing's syndrome.库欣综合征治愈后股骨头缺血性坏死的自发缓解
Endocrinol Diabetes Metab Case Rep. 2016;2016:160015. doi: 10.1530/EDM-16-0015. Epub 2016 May 1.
5
[Bilateral osteonecrosis of the hip secondary to endogenous Cushing's syndrome due to a recently-diagnosed carcinoid tumour of the lung].[因近期诊断出的肺部类癌瘤导致内源性库欣综合征继发双侧股骨头坏死]
Med Clin (Barc). 2016 Sep 2;147(5):228. doi: 10.1016/j.medcli.2016.03.042. Epub 2016 May 18.
6
Evidence for using alendronate to treat adult avascular necrosis of the femoral head: a systematic review.使用阿仑膦酸盐治疗成人股骨头缺血性坏死的证据:一项系统评价。
Med Sci Monit. 2014 Nov 26;20:2439-47. doi: 10.12659/MSM.891123.
7
Enoxaparin prevents steroid-related avascular necrosis of the femoral head.依诺肝素可预防类固醇相关的股骨头缺血性坏死。
ScientificWorldJournal. 2014;2014:347813. doi: 10.1155/2014/347813. Epub 2014 Jul 2.
8
Cushinǵs syndrome and avascular hip necrosis: Presentation of two patients.库欣综合征与缺血性股骨头坏死:两例病例报告
Rev Clin Esp (Barc). 2014 Nov;214(8):e93-6. doi: 10.1016/j.rce.2014.05.003. Epub 2014 Jun 20.
9
Avascular osteonecrosis of femoral head in a postoperative patient of pituitary Cushing's disease.垂体库欣病术后患者的股骨头缺血性坏死
J Assoc Physicians India. 2013 Jun;61(6):413-5.
10
Glucocorticoid-induced avascular bone necrosis: diagnosis and management.糖皮质激素诱导的缺血性骨坏死:诊断与治疗
Open Orthop J. 2012;6:449-57. doi: 10.2174/1874325001206010449. Epub 2012 Oct 5.