Drachler D H, Bower J S, Miller D A, Rotman H H
J Clin Pharmacol. 1977 Nov-Dec;17(11-12):734-9. doi: 10.1002/j.1552-4604.1977.tb01549.x.
A new aerosol bronchodilator, carbuterol, was compared with isoproterenol during a three-month double-blind trial in 15 matched pairs of patients with relatively stable and partially reversible obstructive airways disease. Pulmonary function tests were performed at baseline and at 30 and 120 minutes after bronchodilator administration on days 1, 15, 28, 56, and 84. Isoproterenol and carbuterol produced improvement in all parameters at 30 and 120 minutes. The per cent changes produced by isoproterenol were superior at 30 minutes, while carbuterol was as effective as isoproterenol at 120 minutes. Atrial and ventricular premature contractions and palpitations were more frequent in the isoproterenol group. Evaluation of the patients' symptomatic responses showed carbuterol to be superior to isoproterenol. We conclude that carbuterol is a useful bronchodilator when aerosolized.
在一项为期三个月的双盲试验中，将一种新型气雾剂支气管扩张剂卡布特罗与异丙肾上腺素进行了比较，该试验涉及15对患有相对稳定且部分可逆性阻塞性气道疾病的匹配患者。在第1、15、28、56和84天，于基线以及支气管扩张剂给药后30分钟和120分钟进行肺功能测试。异丙肾上腺素和卡布特罗在30分钟和120分钟时使所有参数均得到改善。异丙肾上腺素在30分钟时产生的百分比变化更优，而卡布特罗在120分钟时与异丙肾上腺素效果相当。异丙肾上腺素组的房性和室性早搏及心悸更为频繁。对患者症状反应的评估显示卡布特罗优于异丙肾上腺素。我们得出结论，雾化后的卡布特罗是一种有用的支气管扩张剂。
