射血分数保留的心力衰竭患者糖尿病的定量蛋白质组学分析
Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction.
作者信息
Hanff Thomas C, Cohen Jordana B, Zhao Lei, Javaheri Ali, Zamani Payman, Prenner Stuart B, Rietzschel Ernst, Jia Yi, Walsh Alice, Maranville Joseph, Wang Zhaoqing, Adam Leonard, Ramirez-Valle Francisco, Schafer Peter, Seiffert Dietmar, Gordon David A, Cvijic Mary E, Cappola Thomas P, Chirinos Julio A
机构信息
Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
出版信息
JACC Basic Transl Sci. 2021 Feb 10;6(2):89-99. doi: 10.1016/j.jacbts.2020.11.011. eCollection 2021 Feb.
Diabetes mellitus (DM) is associated with a higher risk of heart failure hospitalization and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Using SomaScan assays and proteomics analysis of plasma from participants in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial and the Penn Heart Failure Study, this study identified 10 proteins with significantly different expression in patients with HFpEF and DM. Of these, apolipoprotein M was found to mediate 72% (95% CI: 36% to 100%; p < 0.001) of the association between DM and the risk of cardiovascular death, aborted cardiac arrest, and heart failure hospitalization.
糖尿病（DM）与射血分数保留的心力衰竭（HFpEF）患者心力衰竭住院和死亡风险较高相关。本研究利用SomaScan检测法和对TOPCAT（醛固酮拮抗剂治疗射血分数保留的心力衰竭）试验及宾夕法尼亚心力衰竭研究参与者血浆进行的蛋白质组学分析，在HFpEF和DM患者中鉴定出10种表达有显著差异的蛋白质。其中，载脂蛋白M被发现介导了DM与心血管死亡、心脏骤停未遂及心力衰竭住院风险之间72%（95%CI：36%至100%；p<0.001）的关联。
Zotero 插件