Firdous Maryam, Ullah Saif, Shah Mutahir, Qayyum Sadaf, Ansari Muhammad Hasan, Aziz Amtul
Department of Optometry, Pakistan Institute of Ophthalmology, Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan.
Department of Diagnostic, Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan.
Oman J Ophthalmol. 2024 Oct 24;17(3):362-365. doi: 10.4103/ojo.ojo_80_24. eCollection 2024 Sep-Dec.
The purpose of this study was to evaluate and compare the values of hexagonality of endothelial cells among type-2 diabetics and nondiabetics. It also aimed at finding the correlation of the hexagonality of endothelial cells with the duration of diabetes, random blood sugar level, and severity of diabetic retinopathy in type-2 diabetics.
A comparative cross-sectional study was conducted for 8 months from January to August 2022. The data was collected from tertiary care eye hospital named Al-Shifa Trust Eye hospital jhelum road, Rawalpindi, Pakistan. After taking the informed consent, a complete history of each subject was taken. Visual acuity and refraction were performed using Early Treatment Diabetic Retinopathy Study visual acuity chart and then, complete slit-lamp anterior and posterior segment examination was performed followed by specular microscopy (TOMEY Specular Microscope EM-4000) to evaluate endothelial cell hexagonality. The diabetic subjects were checked for their random blood sugar levels immediately after specular microscopy using a digital glucometer and the readings were recorded.
Results showed that the hexagonality of endothelial cells was statistically significantly lower ( = 0.000) in type-2 diabetics than in nondiabetics. Correlation analysis of the hexagonality of endothelial cells showed a negative correlation ( < 0.05) with random blood sugar levels while no correlation ( > 0.05) with the duration of diabetes and severity of diabetic retinopathy.
The study concluded that the hexagonality of endothelial cells was significantly different among the two groups under study, i.e., type-2 diabetics and nondiabetics.
本研究的目的是评估和比较2型糖尿病患者与非糖尿病患者内皮细胞的六角形程度值。它还旨在找出2型糖尿病患者内皮细胞六角形程度与糖尿病病程、随机血糖水平及糖尿病视网膜病变严重程度之间的相关性。
于2022年1月至8月进行了为期8个月的比较性横断面研究。数据收集自巴基斯坦拉瓦尔品第杰赫勒姆路的三级眼科护理医院——阿尔希法信托眼科医院。在获得知情同意后，记录了每个受试者的完整病史。使用早期糖尿病性视网膜病变研究视力表进行视力和验光检查，然后进行完整的裂隙灯眼前段和后段检查，随后进行镜面显微镜检查（托梅镜面显微镜EM - 4000）以评估内皮细胞的六角形程度。在镜面显微镜检查后立即使用数字血糖仪检查糖尿病受试者的随机血糖水平并记录读数。
结果显示，2型糖尿病患者内皮细胞的六角形程度在统计学上显著低于非糖尿病患者（P = 0.000）。内皮细胞六角形程度的相关性分析显示与随机血糖水平呈负相关（P < 0.05），而与糖尿病病程和糖尿病视网膜病变严重程度无相关性（P > 0.05）。
该研究得出结论，在研究的两组人群中，即2型糖尿病患者和非糖尿病患者，内皮细胞的六角形程度存在显著差异。
