Hu Rong, Xu Hai-Peng, He Ke-Lin, Chen Yi, Wu Lei, Ma Rui-Jie
The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China.
Zhongguo Gu Shang. 2021 Jan 25;34(1):91-6. doi: 10.12200/j.issn.1003-0034.2021.01.017.
Perineuronal nets (PNNs) is a complex network composed of highly condensed extracellular matrix molecules surrounding neurons. It plays an important role in maintaining the performance of neurons and protecting them from harmful substances. However, after spinal cord injury, PNNs forms a physical barrier that surrounds the neuron and limits neuroplasticity, impedes axonal regeneration and myelin formation, and promotes local neuroinflammatory uptake. This paper mainly describes the composition and function of PNNs of neurons and its regulatory effects on axonal regeneration, myelin formation and neuroinflammation after spinal cord injury.
神经周网（PNNs）是一种由围绕神经元的高度浓缩的细胞外基质分子组成的复杂网络。它在维持神经元的性能并保护它们免受有害物质侵害方面发挥着重要作用。然而，脊髓损伤后，神经周网形成了围绕神经元的物理屏障，限制了神经可塑性，阻碍了轴突再生和髓鞘形成，并促进了局部神经炎症反应。本文主要描述了神经元神经周网的组成和功能及其对脊髓损伤后轴突再生、髓鞘形成和神经炎症的调节作用。
