Arthritis Unit. Rheumatology Service. Hospital Clinic of Barcelona, Barcelona, Spain.
Department of Biological Chemistry, Unit of Synthesis and Biomedical Applications of Peptides, Institute of Advanced Chemistry of Catalonia, Consejo Superior De Investigaciones Científicas (IQAC-CSIC), Barcelona, Spain.
Expert Rev Clin Immunol. 2021 Apr;17(4):375-384. doi: 10.1080/1744666X.2021.1899811. Epub 2021 Mar 17.
Palindromic rheumatism (PR) is a form of relapsing/remitting arthritis that may evolve to chronic rheumatic disease, mainly rheumatoid arthritis (RA). The exact nature of PR is unclear, as it may be considered a disease in itself, an abortive form of RA or just a pre-RA stage.
The authors review the most relevant epidemiological and clinical aspects of PR, especially the pathogenetic role of autoimmunity in PR, with most patients having a characteristic autoantibody profile similar to that observed in RA. The role of autoinflammation is also discussed. A literature review on the rate of RA progression and its prognostic factors was analyzed. Data on the efficacy of drug therapies used to treat PR are presented. PubMed was searched using the terms 'palindromic rheumatism' OR 'palindromic arthritis'.
PR is a disease entity with a close but unclear relationship with RA. In PR there is an unmet need, which is to clarify the clinical spectrum and elucidate the risk factors for evolution to RA. The role of autoimmunity and the autoinflammatory component should be investigated. Since most patients evolve to RA, PR may display a unique therapeutic opportunity to avoid this evolution.
回纹性风湿病（PR）是一种反复发作/缓解的关节炎，可能发展为慢性风湿性疾病，主要为类风湿关节炎（RA）。PR 的确切性质尚不清楚，因为它可能被认为是一种自身疾病、RA 的一种流产形式，或者只是 RA 的前期阶段。
作者回顾了 PR 最相关的流行病学和临床方面，特别是自身免疫在 PR 中的发病机制作用，大多数患者具有类似于 RA 观察到的特征性自身抗体谱。还讨论了自身炎症的作用。对 RA 进展及其预后因素的发生率进行了文献复习。介绍了用于治疗 PR 的药物治疗的疗效数据。使用术语“回纹性风湿病”或“回纹性关节炎”在 PubMed 上进行了搜索。
PR 是一种具有密切但不明确关系的疾病实体与 RA。在 PR 中存在未满足的需求，即阐明其临床谱并阐明发展为 RA 的危险因素。应研究自身免疫和自身炎症成分的作用。由于大多数患者发展为 RA，PR 可能表现出独特的治疗机会，以避免这种演变。
