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重新审视关节炎:探索其类型及新兴管理策略。

Rethinking arthritis: exploring its types and emerging management strategies.

作者信息

Britto Namrata, Alavala Rajasekhar Reddy, Brijesh S

机构信息

Department of Biological Sciences, Sunandan Divatia School of Science, SVKM's NMIMS (Deemed-to-Be University), V.L. Mehta Road, Vile Parle (W), Mumbai, 400056, India.

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS (Deemed-to-Be University), V.L. Mehta Road, Vile Parle (W), Mumbai, 400056, India.

出版信息

Inflammopharmacology. 2025 Jul 1. doi: 10.1007/s10787-025-01833-8.

Abstract

Arthritis is a complex group of disorders characterized by inflammation of the joints and poses a significant burden on global health. The most prevalent types of arthritis are osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gouty arthritis, ankylosing spondylitis, and juvenile idiopathic arthritis. These types affect millions of individuals worldwide, leading to impaired mobility and reduced quality of life. This review delves into the pathophysiology, clinical manifestations, and progression of these primary arthritis types while shedding light on over 39 lesser-prevalent variants. Traditional management strategies, including pharmacological and non-pharmacological interventions, have shown limited success in halting disease progression and mitigating long-term damage. Consequently, arthritis research has shifted towards emerging therapeutic strategies such as nanotechnology-based drug delivery systems, diet modifications, stem cell, and gene therapy approaches. Telemedicine and artificial intelligence are revolutionizing arthritis care by enabling personalized treatment regimes, improving diagnostic accuracy, and optimizing patient outcomes. This paper underscores the need for a multi-faceted approach to arthritis management, emphasizing micromanagement at the cellular and molecular levels to address the heterogeneity of the disease. Understanding the nuances of different arthritis types and leveraging innovative therapeutic technologies will be paramount in improving patient prognosis and minimizing the societal burden of this debilitating condition.

摘要

关节炎是一组复杂的疾病,其特征为关节炎症,给全球健康带来了沉重负担。最常见的关节炎类型包括骨关节炎、类风湿关节炎、银屑病关节炎、痛风性关节炎、强直性脊柱炎和青少年特发性关节炎。这些类型影响着全球数百万人,导致行动能力受损和生活质量下降。本综述深入探讨了这些主要关节炎类型的病理生理学、临床表现和进展,同时介绍了39种以上不太常见的变体。包括药物和非药物干预在内的传统管理策略在阻止疾病进展和减轻长期损害方面成效有限。因此,关节炎研究已转向新兴治疗策略,如基于纳米技术的药物递送系统、饮食调整、干细胞和基因治疗方法。远程医疗和人工智能正在彻底改变关节炎护理,通过实现个性化治疗方案、提高诊断准确性和优化患者预后。本文强调了采用多方面方法管理关节炎的必要性,强调在细胞和分子水平上进行微观管理以应对疾病的异质性。了解不同关节炎类型的细微差别并利用创新治疗技术对于改善患者预后和最小化这种使人衰弱病症的社会负担至关重要。

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