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专家对肌少症结局的偏好:来自欧洲临床和经济骨矿盐学会(ESCEO)骨质疏松、骨关节炎和肌肉骨骼疾病工作组与欧洲老年医学学会联盟(EUGMS)合作的一项离散选择实验。

Experts' preferences for sarcopenia outcomes: a discrete-choice experiment from a working group of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) in collaboration with the European Union of Geriatric Medicine Society (EUGMS).

机构信息

WHO Collaborating Center for Public Health Aspects of Musculo-Skeletal Health and Ageing, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.

Department of Health Services Research, CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands.

出版信息

Aging Clin Exp Res. 2021 Apr;33(4):1079-1083. doi: 10.1007/s40520-021-01794-2. Epub 2021 Mar 5.

Abstract

BACKGROUND AND AIMS

To assess experts' preference for sarcopenia outcomes.

METHODS

A discrete-choice experiment was conducted among 37 experts (medical doctors and researchers) from different countries around the world. In the survey, they were repetitively asked to choose which one of two hypothetical patients suffering from sarcopenia deserves the most a treatment. The two hypothetical patients differed in five pre-selected sarcopenia outcomes: quality of life, mobility, domestic activities, fatigue and falls. A mixed logit panel model was used to estimate the relative importance of each attribute.

RESULTS

All sarcopenia outcomes were shown to be significant, and thus, important for experts. Overall, the most important sarcopenia outcome was falls (27%) followed by domestic activities and mobility (24%), quality of life (15%) and fatigue (10%).

DISCUSSION AND CONCLUSION

Compared to patient's preferences, experts considered falls as a more important outcome of sarcopenia, while the outcomes fatigue and difficulties in domestic activities were considered as less important.

摘要

背景与目的

评估专家对肌少症结局的偏好。

方法

在来自世界各地不同国家的 37 名专家(医生和研究人员)中开展了一项离散选择实验。在调查中,他们反复被要求选择两名患有肌少症的假想患者中,哪一位最需要接受治疗。这两名假想患者在五个预先选定的肌少症结局方面存在差异:生活质量、移动能力、家务活动能力、疲劳和跌倒。使用混合 Logit 面板模型来估计每个属性的相对重要性。

结果

所有肌少症结局均被证明具有显著意义,因此对专家来说很重要。总体而言,跌倒(27%)是最重要的肌少症结局,其次是家务活动能力和移动能力(24%)、生活质量(15%)和疲劳(10%)。

讨论与结论

与患者的偏好相比,专家认为跌倒肌少症的更重要的结局,而疲劳和家务活动困难被认为是不太重要的结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f30b/8084829/44ed15e8a4ca/40520_2021_1794_Fig1_HTML.jpg

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