Department of Internal Medicine, Geriatric Section, University of Palermo, Palermo, Italy.
Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
Front Endocrinol (Lausanne). 2021 Dec 16;12:804560. doi: 10.3389/fendo.2021.804560. eCollection 2021.
Recent literature suggests that sarcopenia, often represented by low lower limbs muscle mass and strength, can be considered a potential risk factor for knee osteoarthritis (OA), but the available literature is still limited. We therefore aimed to investigate whether sarcopenia is associated with a higher risk of radiographic (ROA) and symptomatic knee OA (SxOA) in a large cohort of North American people in the context of the OA initiative. Sarcopenia at baseline was diagnosed in case of low skeletal muscle mass (i.e., lower skeletal mass index) and poor performance in the chair stands test. The outcomes of interest for this study included ROA (radiographical osteoarthritis) if a knee developed a Kellgren and Lawrence (KL) grade ≥2 at follow-up, and SxOA (symptomatic osteoarthritis) defined as new onset of a combination of painful knee OA. Altogether, 2,492 older participants (mean age: 68.4 years, 61.4% females) were included. At baseline, sarcopenia was present in 6.1% of the population. No significant difference in ROA prevalence was observed between those with and without sarcopenia (p=0.76), whilst people with sarcopenia reported a significant higher prevalence of SxOA (p<0.0001). Using a logistic regression analysis, adjusting for potential confounders at baseline and the diagnosis of sarcopenia during follow-up, sarcopenia was associated with a higher incidence of knee SxOA (odds ratio, OR=2.29; 95%CI [confidence interval]: 1.42-3.71; p=0.001), but not knee ROA (OR=1.48; 95%CI: 0.53-4.10; p=0.45). In conclusion, sarcopenia could be associated with a higher risk of negative knee OA outcomes, in particular symptomatic forms.
最近的文献表明，肌肉减少症（常表现为下肢肌肉量和力量降低）可被视为膝关节骨关节炎（OA）的潜在危险因素，但现有文献仍然有限。因此，我们旨在研究在 OA 倡议的背景下，在北美人的大型队列中，肌肉减少症是否与放射学（ROA）和症状性膝关节 OA（SxOA）的更高风险相关。基线时，如果存在低骨骼肌量（即低骨骼肌指数）和坐立试验表现不佳，则诊断为肌肉减少症。本研究的感兴趣结局包括 ROA（放射学 OA），如果随访时膝关节出现 Kellgren 和 Lawrence（KL）分级≥2；以及 SxOA（症状性 OA），定义为新发膝关节 OA 疼痛。共有 2492 名年龄较大的参与者（平均年龄：68.4 岁，61.4%为女性）被纳入研究。基线时，人群中有 6.1%存在肌肉减少症。有和无肌肉减少症的人群中 ROA 的患病率无显著差异（p=0.76），而肌肉减少症患者报告 SxOA 的患病率显著更高（p<0.0001）。使用逻辑回归分析，调整基线时的潜在混杂因素和随访期间的肌肉减少症诊断，肌肉减少症与膝关节 SxOA 的发生率较高相关（比值比，OR=2.29；95%置信区间[CI]：1.42-3.71；p=0.001），但与膝关节 ROA 无关（OR=1.48；95%CI：0.53-4.10；p=0.45）。总之，肌肉减少症可能与膝关节 OA 不良结局的风险增加相关，特别是与症状性形式相关。
