WELBIO, Avenue Hippocrate 75, 1200 Brussels, Belgium; de Duve Institute, Université catholique de Louvain, Avenue Hippocrate 75, 1200 Brussels, Belgium.
WELBIO, Avenue Hippocrate 75, 1200 Brussels, Belgium; de Duve Institute, Université catholique de Louvain, Avenue Hippocrate 75, 1200 Brussels, Belgium.
Curr Opin Microbiol. 2021 Jun;61:25-34. doi: 10.1016/j.mib.2021.02.003. Epub 2021 Mar 3.
Bacterial lipoproteins are globular proteins anchored to a membrane by a lipid moiety. By discovering new functions carried out by lipoproteins, recent research has highlighted the crucial roles played by these proteins in the cell envelope of Gram-negative bacteria. Here, after discussing the wide range of activities carried out by lipoproteins in the model bacterium Escherichia coli, we review new insights into the essential mechanisms involved in lipoprotein maturation, sorting and targeting to their final destination. A special attention will also be given to the recent identification of lipoproteins on the surface of E. coli and of other bacteria. The renewed interest in lipoproteins is driven by the need to identify novel targets for antibiotic development.
细菌脂蛋白是通过脂质部分锚定在膜上的球形蛋白。最近的研究通过发现脂蛋白所执行的新功能，强调了这些蛋白质在革兰氏阴性菌细胞包膜中的关键作用。在这里，在讨论了模型菌大肠杆菌中脂蛋白执行的广泛活动之后，我们回顾了脂蛋白成熟、分拣和靶向其最终目的地的基本机制的新见解。特别关注还将放在大肠杆菌和其他细菌表面脂蛋白的最新鉴定上。对脂蛋白的重新关注是出于为抗生素开发确定新靶标的需要。
